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The information on this page was reviewed and approved by
Maurie Markman, MD, President, Medicine & Science at CTCA.

This page was updated on July 19, 2021.

Superficial spreading melanoma

In 2021, the National Cancer Institute (NCI) estimates 106,110 people in the United States will be diagnosed with melanoma, a type of skin cancer that affects pigment cells, or melanocytes. These cells help give skin its color.

Melanoma isn’t the most common type of skin cancer, but it’s among the most dangerous due to its tendency to grow and spread. It’s also been steadily on the rise in the past few decades. Still, the overall prognosis of melanoma is good, with a 93.3 percent five-year relative survival rate, according to the NCI. This means that 93.3 percent of people are still alive five years after they’re diagnosed with melanoma.

About 2.3 percent of people in the United States are diagnosed with melanoma at some point in their life, though most people are diagnosed between ages 65 and 74, according to the NCI.

Out of more than 30 different types of melanoma, the most common is superficial spreading melanoma.

What is superficial spreading melanoma?

Superficial spreading melanoma is the most common subtype of melanoma skin cancer, accounting for about 70 percent of cases, according to the NCI.

The name may be long, but it hints at how this type of cancer behaves. “Superficial” refers to the horizontal growth pattern of cancer cells. When it develops, superficial spreading melanoma tends to spread slowly outward but remains for quite a while (sometimes years) in the same layer of the epidermis where it began before invading other layers of tissue.

Symptoms of superficial spreading melanoma

Superficial spreading melanomas may develop anywhere on the skin, but they tend to be found in different places on men and women.

In women, they tend to show up on the legs.

In men, they tend to develop on the:

  • Head
  • Neck
  • Chest
  • Abdomen
  • Back

Superficial spreading melanomas tend to be:

  • Flat or slightly elevated, especially as they grow
  • Dark brown with different shades, including black, blue or pink
  • Asymmetrical with irregular borders
  • Larger than 6 mm across

These melanomas may have indentations within the lesion as well. The average size of a superficial spreading melanoma is about 20 mm, or 2 cm, across.

None of these characteristics make superficial spreading melanoma appear dramatically different from other types of melanoma when seen with the naked eye.

Thus, a good practice for prevention or early diagnosis of any type of melanoma is to take note of changes in the skin with any new or existing moles regarding:

  • Size
  • Shape
  • Color
  • Texture

Causes of superficial spreading melanoma

All types of melanoma are caused by slight changes in genetic material called gene mutations. Some gene mutations are inherited—they may run in the family and be present from birth. Others are ones that develop over time due to different factors. For example, ultraviolet (UV) rays from the sun penetrate a person’s DNA and cause slight changes in the genes. As the cells naturally grow and divide, they may pass on these mutations to new cells.

In melanomas caused by a gene inheritance, researchers have identified the specific gene mutations that lead to melanoma. These include the BRAF oncogene, which is responsible for about half of all melanomas, as well as the genes NRAS, CDKN2A, NF1 and CDK4.

Risk factors for superficial spreading melanoma

Several characteristics increase the chances of developing superficial spreading melanoma. Knowing the risk factors for cancer may help doctor and patient discuss steps for cancer prevention.

The risk factors for melanoma include:

  • Exposure to UV rays: Sunlight and tanning beds both expose people to ultraviolet rays that may increase the risk of skin cancer, including melanoma skin cancer.
  • Fair skin: Light skin with a tendency to burn rather than tan and skin prone to freckles are risk factors for melanoma.
  • Moles: Having many moles, or having atypical moles with an irregular shape and/or color, may pose a higher risk.
  • Age: The average age of diagnosis is 65, but melanoma may develop at any age.
  • Race: Melanoma may affect anyone, but white people are much more predisposed.
  • Family history: If someone in the family has had melanoma, especially a close relative such as a parent or sibling, the risk of developing melanoma is higher. Sometimes this is due to specific gene mutations that have been passed between family members, but often it’s due to having shared risk factors, such as light skin.
  • Prior skin cancer: A previous diagnosis, even if it was for basal cell or squamous cell skin cancer, raises the risk of developing melanoma.

How superficial spreading melanoma is diagnosed

If a patient has a suspicious patch of skin that shows any sign of cancer, there’s typically a standard set of steps that follow.

Doctors may look for any other signs of skin cancer across the body, including feeling the lymph nodes, especially the ones closest to the suspicious spot. Cancer may affect nearby lymph nodes, making them larger.

In order to know if a spot is cancerous, doctors may need to take a sample of tissue, called a biopsy, and inspect the cells. They may remove all suspicious spots detected.

There are a few different ways to perform a skin biopsy.

  • Reflectance confocal microscopy (RCM): This newer, noninvasive “optical biopsy” may be done without cutting into skin. It allows doctors to see some layers into the skin without surgery. This procedure may be used to prevent an unnecessary biopsy procedure in the event that the doctor is very unsure whether a particular spot is cancerous.
  • Excisional biopsy: Doctors remove the entire tumor for inspection, including a margin around the tumor.
  • Punch biopsy: Doctors use an instrument to cut out a small cylinder of skin and study several layers of skin.

Other types of biopsies, such as shave biopsies or incisional biopsies, in which only a part of a tumor is removed, may be used to diagnose melanoma but aren’t as common.

After the biopsy, a pathologist looks at the removed tissue under a microscope and may be able to tell right away if the sample shows melanoma or not. The pathologist may also need to do additional tests to confirm melanoma or to confirm which genes have mutated to cause the melanoma.

Additional imaging tests may be done if a doctor is concerned that the melanoma has spread. These may include:

Results from any or all of these tests guide doctors in staging a melanoma, or figuring out how much it has spread, if any.

How is superficial spreading melanoma treated?

The most common treatment for most superficial spreading melanoma is to have it removed surgically. This may or may not include having surgery to remove affected lymph nodes as well.

Even for melanoma that has spread to distant parts of the body, surgery may be able to remove cancer from those sites. Treatment for advanced melanoma may include systemic drug therapy—such as chemotherapy, immunotherapy or targeted therapy—as well.

If melanoma returns after treatment, called recurrent melanoma, part of the treatment may involve injecting a cancer-targeting virus into the melanoma lesion itself. Through this therapy, called oncolytic therapy, a virus works in tandem with the body’s immune system to fight cancer cells.

The treatment plan depends on several factors. Along with a cancer care team, the patient must take into account:

  • Overall health
  • Age
  • Cancer stage
  • Treatment goal
  • Treatment side effects

Superficial spreading melanoma survival rates

When compared with the survival rates of all melanomas together, superficial spreading melanoma survival rates tend to be slightly higher, regardless of the stage at diagnosis. The five-year survival rate represents the percentage of people still alive five years after a cancer diagnosis.

According to a 2016 study in BMC Cancer, the survival rates for superficial spreading melanoma are:

  • 99.2 percent survival rate, for local superficial spreading melanoma that hasn’t spread from the site where it started.
  • 71.5 percent survival rate, for regional superficial spreading melanoma that has spread to nearby tissues or lymph nodes.
  • 33.8 percent survival rate, for distant superficial spreading melanoma that has spread to distant parts of the body.

While the survival rates of superficial spreading melanoma are promising overall, there’s still a lot about this type of melanoma—and others—that researchers don’t know yet.

In general, the two most common types of melanoma, superficial spreading and nodular, were thought to be different only in their initial directions of growth. Superficial spreading melanoma grows outward, spreading across the epidermis at first and may take years to invade other tissue layers, while nodular melanoma immediately spreads into different layers of surrounding tissue.

However, a research review from 2012 in Melanoma Research shows that there may be more complex genetic distinctions between these two types of melanoma than were previously realized, which may aid in the development of additional treatment approaches.

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