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Karan Shah,

M.D., M.B.A.

Radiation Oncologist; Chief of Radiation Oncology, City of Hope Cancer Center Chicago

5 (83 Ratings)
Biography photo
The effects of cancer span a wide spectrum - physical, mental, emotional, social and even financial. City of Hope is unique in that it provides services to address all these aspects and more.
Location
City of Hope Chicago
2520 Elisha Ave.
Zion, IL 60099
Specialties
Radiation Oncology
Education
Medical school:

Loyola University Chicago, Stritch School of Medicine, Maywood, IL

Residency:

Radiation Oncology - Loyola University Medical Center, Maywood, IL

Advanced degrees:

MBA, Healthcare Management & Finance - Loyola University Chicago, Graduate School of Business, Chicago, IL

Academic Appointments
  • Assistant Clinical Professor, Department of Radiation Oncology
Certifications
Radiation Oncology - American Board of Radiology
About Me

For Dr. Karan Shah, Radiation Oncologist at City of Hope Chicago, a career in medicine was the inevitable choice. “Being a doctor allows me to merge my interest in the human body with my desire to make a positive difference in the world,” he says. 

Born in India, Dr. Shah came to the United States at age 12. He completed his Bachelor of Science in Biology, with a minor in biostatistics and accounting, at Loyola University Chicago, where he also completed a Masters in Business Administration with concentration in healthcare management and finance. He completed his Doctor of Medicine at Loyola University Stritch School of Medicine in 2010, attending on a full-tuition merit scholarship and receiving the President's Medallion for outstanding achievement in his final year.

Dr. Shah completed a Transitional Internship at Resurrection Medical Center in Chicago from 2010 to 2011. He completed his Residency in Radiation Oncology at Loyola University Medical Center, becoming Chief Resident in 2014.

During residency, Dr. Shah published original research on head and neck cancer and radiation oncology in several peer-reviewed medical journals. He authored a phase I protocol investigating the combination of intraoperative radiotherapy with kyphoplasty to treat spinal metastases. He is a member and serves on the Health Policy Council of the American Society for Radiation Oncology and he serves as Clinical Assistant Professor at the Rosalind Franklin University of Medicine and Science in North Chicago, Illinois.

Dr. Shah joined the radiation oncology department at City of Hope Chicago in August 2015. He has expertise in the use of 3D conformal radiation, intensity modulated radiation therapy, stereotactic radiosurgery, stereotactic body radiation therapy, intraoperative radiation therapy, brachytherapy, hyperthermia, and radiopharmaceutical therapy. Dr. Shah has a strong interest in clinical research and in particular, writing investigator-initiated clinical trials to examine new innovative approaches to treating cancer. “My overall goal is to be able to cure the cancer using the most optimal treatment modalities combined with an individual, patient-centered focus,” says Dr. Shah, “and to provide effective comprehensive cancer care.”

When he is not at City of Hope, Dr. Shah enjoys basketball, music, travel, leisure reading and spending time with family and friends.
Patient reviews
The patient ratings and comments on this page are obtained from an external Press Ganey® outpatient survey provided to all eligible City of Hope patients within one to two weeks of their treatment occurrence. Raw data from the answers to the survey questions about our physicians are calculated by Press Ganey into a one- to five- star rating. In the spirit of transparency, all patient comments are posted as written by the patient, whether they are positive or negative. We only exclude comments if they are deemed to be slanderous or libelous, contain profanity or vulgar language, or do not relate to the patient's experience with the doctor involved. As a result, the comments are the views and opinions of the patients surveyed and are not endorsed by, and may not necessarily reflect the opinion of, City of Hope.
Mar 8, 2026
"My care from Dr Shah and the entire radiation department was compassionate, supportive, and knowledgeable. I couldn't thank them enough."
Nov 12, 2025
5.0
"Yes Dr Karan explain to me everything that I needed to know [...] "
Nov 6, 2025
5.0
"This practice is very highly recommended."
Nov 6, 2025
5.0
"I was extremely satisfied will the entire staff from receptionist to the Doctors. They were all courteous and professional. I would recommend them all very highly.."
Nov 4, 2025
5.0
"In person visit. Complete staff was excellent All questions were answered and I was treated professionally from registration to the doctor."
Oct 10, 2025
5.0
"Dr Shah is great listener and went the extra mile by calling me at home when he changed my radiation treatments from 10 to 15. I'd highly recommend him! And he communicates with phrases/words I understand."
Oct 4, 2025
5.0
"Dr. Shah was the best explainer of medical information in plain simple terms and the most patient and caring doctor and person.He spent time with us and answered all our questions and addresses all our concerns. Thanks!"
Oct 4, 2025
5.0
"[...] Dr. Shah was the best explainer of medical information in plain simple terms and the most patient and caring doctor and person.He spent time with us and answered all our questions and addresses all our concerns. Thanks!"
Sep 15, 2025
5.0
"[...] The visit went very well. Dr. Shah explained things very well and answered any questions that I had."
Sep 9, 2025
5.0
"Dr. Shah is an amazing doctor. He is so good at explaining everything and listening to all your concerns."
Sep 7, 2025
5.0
"I always recommend COH"
Sep 6, 2025
5.0
"Have already recommended city of hope to a new patient"
Aug 15, 2025
5.0
"Very good"
Aug 15, 2025
5.0
"Very good"
Aug 6, 2025
5.0
"[...] I have recommended this facility to friends and family."
Aug 6, 2025
5.0
"My care provider was clear and covered every question I had. She made me feel like I was in the best hands for my condition, she also understood my religious beliefs concerning the medical use of blood and assured me my surgery would not compromise my faith based decision that no blood be used. That eased 90%of the stress of this experience. She is a true professional."
Jul 24, 2025
5.0
"It's hard for me to say, but they are the best team in the world, they take care of me like a little child, I feel safe here and I like visiting them (They're great)"
Jul 24, 2025
5.0
"My doctor is great; I ask me everything, and Karan Shah is a great doctor. Nurse [...] tells me how to take my medications, and she's great at it. The entire team is the best in the world. The ladies who work in the office are very kind and helpful."
Jun 27, 2025
5.0
"Very good"
Jun 27, 2025
5.0
"Very good"
Jun 25, 2025
5.0
"I have already recommended City of Hope to others"