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Soft tissue sarcoma symptoms

This page was reviewed under our medical and editorial policy by
Maurie Markman, MD, President, Medicine & Science at CTCA.

This page was updated on June 6, 2022.

As with many forms of cancer, symptoms of soft tissue sarcoma may appear at a more advanced stage of the disease—or the patient may not notice any symptoms at all. If they are present, symptoms will also vary depending on the type of sarcoma and its location.

Since soft tissue sarcomas may start in any type of soft tissue—including fat, muscle, nerves and more—these cancers may grow almost anywhere in the body. However, most (60 percent) start in the arms or legs, according to the American Society of Clinical Oncology. Other common areas where a sarcoma may develop include the torso or abdomen (where 30 percent of soft tissue sarcomas occur) and the head or neck (10 percent).

Soft tissue sarcomas may spread, or metastasize, beyond where the cancer starts. Metastasis occurs when cancer cells travel through the bloodstream or lymph system and reach other parts of the body.

When soft tissue sarcomas metastasize, the lungs are the most common site of spread. About 83 percent of metastatic soft tissue sarcomas affect the lungs, according to a 2018 review in Pharmacy and Therapeutics. Certain types of soft tissue sarcomas may be more likely to spread to other places. Myxoid liposarcomas may spread to the pelvis or abdomen, while angiosarcomas or alveolar soft part sarcomas may spread to the brain.

Symptoms of soft tissue sarcoma include:

A lump or mass, the most common soft tissue sarcoma sign. The lump forms in the area in which the tumor is growing, and it may be accompanied by some pain if it’s pressing on a nerve or muscle. Even if the lump isn’t painful, if it continues to grow, or if it’s located deep within an extremity or body cavity, consult your doctor. Sarcomas that grow in tissue near the skin's surface may easily move when touched, while those embedded deeper under the skin may be more fixed in place. They’re typically larger than the size of a golf ball, which is around 4 cm across. Whether or not the lump is painful is generally not considered an important factor in distinguishing a sarcoma from something else.

Uncomfortable swelling, especially when it’s located in the arms and legs

Limited mobility, resulting from a tumor that restricts motion (such as those found in the hips, knees, shoulders or hands)

Skin lesions, which may occur when a sarcoma tumor breaks through the skin

Because a sarcoma tumor may form almost anywhere in the body, it may affect a variety of organs. For example, sarcomas in the abdomen may cause abdominal pain, vomiting or constipation, while sarcomas in the uterus may cause vaginal bleeding and/or abdominal pain. With gastrointestinal stromal tumors (GISTs), you may feel full after eating very small meals, or you may vomit blood or have dark bowel movements. Sarcomas that begin in the lungs or heart may lead to symptoms such as chest pain and breathing problems.

Signs that should lead you to see a doctor immediately include:

  • A new lump or one that’s growing
  • Worsening abdominal pain
  • Black, tarry or bloody stools
  • Bloody vomit

Surgery

Soft-tissue sarcoma may be difficult to spot, and many of the symptoms associated with this cancer are often caused by something more common than a sarcoma. However, if you’re experiencing symptoms associated with this cancer, it’s important to visit a doctor to find out the cause.

To diagnose a soft tissue sarcoma, your doctor may start by conducting a physical exam to feel for lumps suspected to be a sarcoma. Imaging tests may be the next step, such as an X-ray or ultrasound, to take a deeper look at potential areas of cancer in the body. More detailed scans, such as a computed tomography (CT) scan or magnetic resonance imaging (MRI), may also be used.

Imaging tests help indicate whether you have a sarcoma, but a biopsy is typically needed to confirm the diagnosis and determine the type of sarcoma.

According to the American Cancer Society, there are more than 50 distinct soft tissue sarcoma types, so it’s important to see a doctor who is knowledgeable about sarcomas.

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