The information on this page was reviewed and approved by
Maurie Markman, MD, President, Medicine & Science at CTCA.

This page was updated on September 21, 2021.

Postmastectomy pain syndrome (PMPS)

Recovery after any type of surgery may be difficult, but a mastectomy may leave some patients with longer-term pain beyond the recovery stage. When post-op pain in your chest, armpit or arm doesn’t go away after a few months, you could have postmastectomy pain syndrome, or PMPS.

Here’s how to tell whether this may be happening and, more importantly, how to find relief.

What is postmastectomy pain syndrome?

It’s normal after a mastectomy, especially with breast reconstruction, to be dealing with stiffness, swelling or a wound that drains fluid as you recover, in addition to the mental toll the procedure may take. You’ll likely have pain immediately after your surgery as well. But prolonged discomfort and pain could mean more than a lengthy healing process. It could signal PMPS.

Despite its name, it’s possible to develop this condition after breast-conserving surgeries, like lumpectomies, as well.

There’s no standard agreement on how long you need to be in pain after breast surgery for it to be considered PMPS. Experts are looking at how to better define and diagnose PMPS. For instance, research clinicians in the Canadian Journal of Surgery have proposed that PMPS be defined as moderate to severe nerve-like pain in the breast or underarm area that lasts more than six months and felt about 50 percent of the time, sometimes brought on by shoulder movements.

The exact cause of postmastectomy pain syndrome isn’t known, but the most common theory is that it happens when a nerve—or nerves—become damaged during surgery. If left untreated, PMPS may not only be painful, but it may also affect the use of your arm and its range of movement, while also impairing your mental health.

What are the symptoms of PMPS?

Because PMPS is nerve pain-specific, the symptoms tend to involve symptoms like shooting pain, stabbing pain, prickling pain, tingling, itchiness or numbness. It may be challenging for providers to distinguish neuropathic pain from other types of pain, so it’s helpful to write down symptoms as you experience them. Be as specific as possible when describing how the pain feels, how often it happens and when it happens.

Symptoms of PMPS may include:

  • Pain and tingling in the chest wall
  • Pain and tingling in the armpit
  • Pain and tingling in the arm
  • Pain in the shoulder
  • Pain in the surgical scar
  • Numbness
  • Shooting or pricking pain
  • Intense itching

Who develops PMPS?

The American Cancer Society notes that anywhere from 20 to 30 percent of people have PMPS after surgery, and some studies report this number may be higher. No standard definition of PMPS currently exists, but as clinicians work to create one, that number may become more exact.

You may be more likely to have persistent postmastectomy pain, including pain from lymphedema (swelling due to undrained lymph fluid) and musculoskeletal pain, due to your:

Age: While no specific age bracket is associated with having PMPS versus not, a research review in the October 2016 issue of the Canadian Medical Association Journal found that younger age showed a greater likelihood of persistent pain. So, a woman who is 40 may have a higher risk of post mastectomy persistent pain than a woman who is 60.

Race or ethnicity: Racial and ethnic minorities are more likely to experience persistent postmastectomy pain, possibly because specific groups—namely African Americans and Hispanics—tend to be diagnosed at more advanced stages of breast cancer.

Treatment type: You’re more likely to have PMPS if you had a surgery that removed tissue in the upper outside portion of the breast or the underarm area, or if you had an axillary lymph node dissection (ALND) that removed 10 to 14 lymph nodes to check for cancer. Women who were treated with breast cancer radiation therapy after surgery are also more likely to have PMPS.

Mental health: There’s some evidence that having a condition like anxiety or depression prior to surgery increases the likelihood you’ll have persistent pain after, according to a December 2018 study in the Journal of Pain.

Previous pain: Evidence also points to a connection between pre-existing pain, such as headaches or low back pain, and the chance you’ll have persistent post-surgery pain.

How is PMPS treated?

If you’re experiencing pain after a mastectomy or lumpectomy, talk to your cancer care team. They may get you the help you need to be as comfortable as possible as you continue to recover. It’s important to address PMPS with medications and treatments that work specifically for nerve pain. Standard painkillers and even strong opioid medications don’t work well for this type of pain, though NSAIDs, or non-steroidal anti-inflammatories like aspirin, may help other types of discomfort you’re going through.

Some current treatments for PMPS include:

Medications: As their names suggest, antidepressants and anti-epileptic medications are typically used to treat depression and epilepsy, but their utility goes beyond those uses—they’re also used to treat PMPS.

Topical capsaicin: This is an ointment, cream or other substance that may be applied to the skin. Capsaicin is found in chili peppers and works by decreasing activity, and therefore the sensation of pain, in nerve cells.

Autologous fat grafting: It’s a relatively new therapy and still being studied, but when fat is grafted from other parts of the body and injected into the breast, it may reduce pain by providing cushioning, while also having an anti-inflammatory effect on the tissue around it.

You may also find relief with integrative therapies, such as acupuncture, yoga or therapeutic massage, but researchers are still looking at whether these or other therapies are helpful to nerve-related pain. Be sure to discuss these ideas with your care team and ask for referrals to providers experienced with PMPS.