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Vaccines

Unlike traditional vaccines intended to directly prevent diseases such as polio, small pox or measles, cancer vaccines do not directly attack the disease. Still, vaccines are critical to the prevention of many cancers and in the treatment of others.

A vaccine introduces a small amount of weakened or mutated disease cells into the body. Although it is not enough to make a patient sick, the vaccine has enough cells to help the body build antibodies to recognize and fight off the disease. Depending on the vaccine, the body may know how to prevent certain diseases for an entire lifetime, or the patient may need a booster, or “reminder,” to continue to ward off the disease.

Cancer vaccines come in two categories:

Prophylactic or preventative vaccines work by killing viruses that may lead to cancer. The only vaccine approved to prevent cancer is:

  • Human papillomavirus (HPV) vaccine: The U.S. Food and Drug Administration has approved several vaccines to prevent HPV infection, which target high-risk HPV strains responsible for nearly all cervical cancers and linked to some throat, anal and other cancers.

Therapeutic or treatment vaccines are designed to stimulate the immune system to attack cancer cells. Therapeutic cancer vaccines now in use include:

  • Sipuleucel-T: This vaccine is used to help treat advanced prostate cancer. Each dose is made specifically for each patient, using the patient’s own immune cells to seek and attack prostate cancer cells. This treatment typically takes six weeks and is administered in three infusions every two weeks.
  • Bacillus Calmette–Guérin (BCG) vaccine: Originally developed for tuberculosis, the BCG vaccine is approved to treat bladder cancer. BCG is live bacteria injected into the bladder via a catheter. The bacterium attracts immune cells, which then attack cancer cells when the vaccine works as designed.