The information on this page was reviewed and approved by
Maurie Markman, MD, President, Medicine & Science at CTCA.

This page was updated on May 14, 2021.

Gestational trophoblastic disease treatments

Treatment for GTD typically includes surgery and/or chemotherapy. Surgery is usually the first treatment option for molar pregnancies, which account for most cases of GTD.


Common surgical options for GTD include:

Suction dilation and curettage (D&C) and hysterectomy: The doctor removes the tissues from the uterus by suctioning the uterus walls, then scraping them. Commonly used in the case of a molar pregnancy, a D&C helps preserve a woman’s fertility. Side effects may include vaginal bleeding, scarring, cramping, infection and blood clots. In most cases, a D&C is the only surgical treatment a GTD patient needs.

Hysterectomy: In some cases, either to reduce the risk of recurrence or to treat PSTT or ETT, a hysterectomy is performed. In a hysterectomy, the uterus and cervix are typically removed. Women who undergo a hysterectomy are no longer able to get pregnant. Side effects may include vaginal bleeding, infection and pain.


Chemotherapy may be used alone as a treatment, or in combination with surgery. It’s commonly used to treat molar pregnancies.

Next topic: What are the risk factors for gestational trophoblastic disease?