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Zoe MacIsaac,

M.D.

Plastic Surgeon

4.8 (141 Ratings)
Biography photo
My goal is to understand my patients' goals and work closely with them to restore normal function and appearance.
Location
City of Hope Phoenix
14200 West Celebrate Life Way
Goodyear, AZ 85338
Specialties
Plastic Reconstructive Surgery
Education
Medical school:

University of Virginia School of Medicine, Charlottesville, VA

Residency:

Integrated Plastic Surgery - University of Pittsburgh Medical Center, Pittsburgh, PA

Fellowship:

Craniofacial Biology Research - University of Pittsburgh, Pittsburgh, PA

Certifications

Board Certified Plastic Surgery - American Board of Plastic Surgery

About Me

Dr. Zoe MacIsaac joined City of Hope Phoenix in 2019. As a plastic surgeon, Dr. MacIsaac works closely with each patient to examine, assess and address surgical needs.

Dr. MacIsaac's work at City of Hope focuses on breast cancer reconstruction, as well as complex reconstruction of the head and neck, the extremities and other areas. She performs primary and secondary breast reconstruction after mastectomy, including reconstruction following nipple-sparing mastectomy and reconstruction after lumpectomy, including oncoplastic rearrangement and oncoplastic breast reduction. Dr. MacIsaac's techniques are tailored to each individual patient and ranges from fat grafting to tissue expander and implant-based reconstruction. In addition, she performs completely autologous procedures using only the patient's own tissue during breast reconstruction.

A native of Nova Scotia, both of Dr. MacIsaac's parents were family practice doctors. At age nine, her family moved to the United States, and she continued learning about medicine from her parents. Dr. MacIsaac knew she wanted to help others, and also wanted to pursue her passion for design and working with her hands. Plastic surgery was a great career path, allowing Dr. MacIsaac to combine these interests.

“Plastic surgery involves many options, steps and outcomes,” says Dr. MacIsaac. “In order to establish clear expectations, I place a priority on encouraging clear and informative communication. I involve my patients along every step of the way, to best understand my patients. Trust and open communication promote the most successful outcomes.”

Dr. MacIsaac received a bachelor's degree in biological sciences from the University of Virginia in Charlottesville, Virginia. She earned a medical degree from the University of Virginia School of Medicine in Charlottesville. Dr. MacIsaac completed an integrated plastic surgery residency at the University of Pittsburgh Medical Center in Pittsburgh, Pennsylvania. She also completed a fellowship in craniofacial biology research at the University of Pittsburgh in Pittsburgh, Pennsylvania.

Dr. MacIsaac is a member of several professional organizations including the American Medical Association, American Society of Plastic Surgeons and American Society for Aesthetic Plastic Surgery. She has authored 26 peer reviewed papers, authored book chapters, published 16 abstracts and given over 126 presentations at professional local, regional, national and international meetings.

When not working, Dr. MacIsaac enjoys spending time with friends and growing family. She likes playing the piano, exploring the outdoors, exercising and running. Dr. MacIsaac has completed several marathons and has also climbed Mount Kilimanjaro.
Patient reviews
The patient ratings and comments on this page are obtained from an external Press Ganey® outpatient survey provided to all eligible City of Hope patients within one to two weeks of their treatment occurrence. Raw data from the answers to the survey questions about our physicians are calculated by Press Ganey into a one- to five- star rating. In the spirit of transparency, all patient comments are posted as written by the patient, whether they are positive or negative. We only exclude comments if they are deemed to be slanderous or libelous, contain profanity or vulgar language, or do not relate to the patient's experience with the doctor involved. As a result, the comments are the views and opinions of the patients surveyed and are not endorsed by, and may not necessarily reflect the opinion of, City of Hope.
Apr 8, 2026
5.0
"The overal place and peole were great"
Mar 29, 2026
5.0
"She is particularly good about giving options & background information"
Mar 22, 2026
5.0
"Dr. MacIsaac is a very kind person. She is very knowledgeable and explains information allowing for questions."
Mar 22, 2026
5.0
"I have told many friends and family, I am so grateful that I have City of Hope so close by and got referred to them. If anyone is diagnosed with Cancer, I would ask for a referral to COH."
Feb 24, 2026
5.0
"Dr. MacIsaac is a miracle worker and very kind and caring. She "corrected" the damage to my forehead after a crainiotomy at [...]. Zoe called my surgeons and explained to them what she would do to fix my forehead. They gave their permission. Dr. MacIsaac made me look "normal" again instead of a sunken deformed forehead. Again...she is a miracle plastic surgeon!!!"
Feb 20, 2026
5.0
"She was so good I have already recommended her to a couple breast cancer survivor friends and will continue to do so."
Feb 10, 2026
5.0
"Dr MacIssac is the very best! COH is lucky to have her!"
Jan 20, 2026
5.0
"Dr MacIsaac is everything you would like to have in your doctor and surgeon. She's patient, takes her time listening and explaining, she's kind, and has a great personality. Add that to her amazing qualifications and talent, and she's just about perfect. I hope COH treats her like the gem that she is."
Jan 5, 2026
5.0
"She always puts me first and takes whatever amount of time is needed to answer all my questions, while never making me feel rushed or as if I'm bothering her."
Jan 1, 2026
5.0
"[...] Dr MacIsaac does not freely share information or engage in discussions about treatment until AFTER you ask a specific question or have a specific issue you want to discuss with her. Even then, she is vague and not forthcoming. It is like pulling teeth to get any information out of her. She wants to decide what is best with you and you are supposed to just go along with it without any explanation or discussion. [...]"
Dec 31, 2025
5.0
"I have already recommended to other people"
Dec 15, 2025
3.1
"Did not provide comprehensive overview of possible risks, did not provide overview of possible negative outcomes and how to address at home, do not feel respected as a partner in health care about decisions or given autonomy about my own body"
Nov 23, 2025
5.0
"Dr took the time to personally call me at home to discuss the results of my test"
Nov 22, 2025
4.9
"[...] I have had wonderful care at the City of Hope."
Nov 22, 2025
4.9
"Dr. MacIsaac is the most pleasant, easy going physician I have ever encountered."
Oct 30, 2025
5.0
"Dr MacIsaac was kind, understanding, through, and made me feel seen and heard. She was not dismissive to my concerns but understanding"
Oct 21, 2025
5.0
"Everything was provided perfectly- I love all my team so much!"
Oct 21, 2025
5.0
"My surgeon is great, super good bedside manner."
Oct 16, 2025
4.9
"I felt validated after meeting and talking with this physician."
Aug 25, 2025
5.0
"Love Dr MacIsaac"
Aug 25, 2025
5.0
"Excellent care EVERY time"
Jul 20, 2025
5.0
"Dr. MacIsaac has been excellent. She has proposed treatment options in my best interest, but also made sure I was included in my own decision-making. This is so valuable in a provider during this difficult time."