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Wade Smith,

M.D.

Medical Oncologist and Hematologist

4.8 (167 Ratings)
Biography photo
Location
City of Hope Newport Beach
1601 Avocado Avenue
Newport Beach, CA 92660
City of Hope Comprehensive Cancer Center - Duarte
1500 East Duarte Road
Duarte, CA 91010
City of Hope Orange County Lennar Foundation Cancer Center
1000 Five Point
Irvine, CA 92618
Specialties
Breast Oncology
Medical Oncology
Education
Medical school:
  • 1995-1999, Doctor of Medicine, M.D., Creighton School of Medicine, Omaha, Nebraska
  • 1991-1995, Bachelor of Science, Biology (Cum Laude), Loyola Marymount University, Los Angeles, California
Residency:
  • 2000-2002, Residency, Internal Medicine, Emory University School of Medicine, Atlanta, GA
Academic Appointments
  • Assistant Clinical Professor, Department of Medical Oncology & Therapeutics Research
  • Director of Research, Newport Beach
About Me

Wade Michael Smith, M.D., is a medical oncologist and hematologist at City of Hope® Newport Beach, where he provides expert cancer care for a wide range of cancer types and serves as the location’s director of research. Dr. Smith brings years of training and experience to his role, and a philosophy founded on personalized, compassionate care. 

Dr. Smith earned his undergraduate degree in biology at Loyola Marymount University in Los Angeles. He went on to receive his medical degree from Creighton University in Omaha, Nebraska, then completed both his residency and fellowship at Emory University School of Medicine in Atlanta. He later returned to Southern California to continue his work helping patients through their cancer journey. 

While Dr. Smith treats a variety of cancers, he has a focus on treating breast cancer. His lifelong interest in biology has also led him to explore new treatments for cancers that do not respond well to conventional chemotherapy, and he is especially excited about helping bring these promising therapies from the lab into the clinic. 

Dr. Smith values how City of Hope has grown its presence in communities across Southern California while staying true to its mission of providing top-quality, patient-centered cancer care close to home.

Patient reviews
The patient ratings and comments on this page are obtained from an external Press Ganey® outpatient survey provided to all eligible City of Hope patients within one to two weeks of their treatment occurrence. Raw data from the answers to the survey questions about our physicians are calculated by Press Ganey into a one- to five- star rating. In the spirit of transparency, all patient comments are posted as written by the patient, whether they are positive or negative. We only exclude comments if they are deemed to be slanderous or libelous, contain profanity or vulgar language, or do not relate to the patient's experience with the doctor involved. As a result, the comments are the views and opinions of the patients surveyed and are not endorsed by, and may not necessarily reflect the opinion of, City of Hope.
Mar 5, 2026
5.0
"Very , very good experience"
Mar 5, 2026
5.0
"Only very good experience"
Feb 27, 2026
5.0
"I have already recommended Dr Smith to a few people who seek a well experienced oncologist."
Feb 9, 2026
5.0
"Dr. Smith is and always has been the best doctor I could have been blessed with. His personality, care, and knowledge make me feel encouraged and grounded."
Feb 5, 2026
5.0
"All good"
Feb 5, 2026
5.0
"All good"
Jan 28, 2026
5.0
"Excellent caring and knowledgeable doctor (Dr. Wade Smith)"
Jan 24, 2026
4.3
"I had a breast MRI many months ago and I have yet to hear the results. I traveled from [...] to Irvine for a zometa infusion and appointment with Dr. Smith and he hadn't seen the MRI and his staff couldn't find it while I was there. I asked to be told the results when they find and I have heard nothing. Days later, a staff member called me about it, asking where I got my MRI and saying they'd get back to me with the results. I still haven't heard from them. [...] COH called me to tell me that Dr. Smith has ordered a mammogram. I brought up the breast MRI and she leave a note for Dr. Smith and his staff. I'm really disappointed that all this time, no one has reviewed my imaging. That I drive all the way for my appointment that was scheduled far in advance, and no one can find the MRI."
Jan 17, 2026
4.3
"Dr Wade Smith was so helpful. I've contacted him for a second opinion, potential changes in my treatment, several times. He has always been very upfront about his opinion & I very much appreciate his candor."
Jan 17, 2026
4.3
"I am very pleased with his assistance in my care & would not hesitate to recommend Dr Smith. If his office wasn't so far away (I live in [...]) I would definitely ask him to be my primary oncologist."
Jan 4, 2026
4.3
"Dr. Wade Smith is a consistently strong listener - he always answers my (many) questions with thoughtfulness, consideration and care. Dr. Smith's responses are informative, helpful and clear. I always feel like I've been well cared for after all of my visits with Dr. Smith. Regarding recommendations - Not too long ago, I recommended Dr. Smith to a fellow patient while waiting in the lobby at Lennar. The woman was concerned about beginning care and I shared that I've been really happy with Dr. Smith and it turns out that she already had an initial appointment with him. She was so relieved to speak with me and felt better that I had recommended him :) I recommend Dr. Smith and COH whenever appropriate."
Jan 2, 2026
5.0
"Very thorough, gentle, thoughtful, precise, knowledgeable and personable. Excellent!"
Jan 2, 2026
5.0
"Would recommend in a heartbeat to anyone. Top notch care with professionals at the top of their field."
Jan 1, 2026
5.0
"Dr Laurie Brunette was nice, empathetic, informative and helped alleviate my fears and concerns."
Jan 1, 2026
5.0
"Dr Smith actually probably saved my life by ordering a test that discovered blood clots"
Jan 1, 2026
5.0
"The best place with the best people is priceless , especially as we get older and it's harder to be your own advocate. City of Hope truly gives hope"
Nov 28, 2025
2.4
"This provider was in a hurry to go to the next patient."
Nov 28, 2025
5.0
"I have already recommended Dr Smith and Newport location to a few patients."
Nov 28, 2025
5.0
"I always have satisfied discussions with Dr Smith about new medications, trials and next steps. I have already recommended Dr Smith to a few patients who seek for a well-experienced oncologist [...]. They are satisfied with knowledge and experience and care received by Dr Smith."
Nov 7, 2025
5.0
"Dr. Smith is the Best Dr. I could have ever hoped for. He has been with me since the beginning of my journey and I trust him with my life."
Sep 21, 2025
4.9
"Dr Smith is great"
Aug 30, 2025
5.0
"Only exlent experience"
Aug 30, 2025
5.0
"Very nice place and clean"
Aug 24, 2025
5.0
"Dr. Smith is a very good care provider"
Aug 18, 2025
5.0
"Good"
Aug 18, 2025
5.0
"Again, good"
Aug 18, 2025
5.0
"Thorough visit and extremely concerned Doctor! Dr. Wade Smith Thank you"
Aug 17, 2025
5.0
"I have been coming to the City of Hope for just a few months. Since the first time I've always been treated and respected by precision and kindness."
Aug 16, 2025
5.0
"I am a difficult patient but Dr. Wade Smith is always professional and considerate."
Aug 13, 2025
5.0
"I received very good care from Dr Wade Smith and his team. [...]"
Aug 1, 2025
5.0
"It was a very supportive experience in every way. From the receptionists to the nurses and of course Dr. Smith."
Aug 1, 2025
5.0
"Dr. Smith is a knowledgeable and compassionate doctor. He was so kind and answered all my questions. It is so scary to be dealing with cancer. Dr. Smith is so supportive and I feel like I have the best care from him."
Jul 25, 2025
5.0
"I've always been very pleased with Dr. Smith's care of myself and other family members."
Jul 25, 2025
5.0
"Incredible !"
Jul 25, 2025
5.0
"Dr Smith is an excellent listener and caring!"
May 28, 2025
5.0
"Very good experience"
May 28, 2025
5.0
"Only very good people"
May 24, 2025
5.0
"Good"
May 23, 2025
5.0
"Dr. Smith said the entire team are wonderful"
May 22, 2025
5.0
"I visited Dr. Smith for a second opinion regarding my cancer medication treatment options."