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Matthew Lee,

M.D.

Medical Oncologist

4.9 (81 Ratings)
Biography photo
Location
City of Hope Comprehensive Cancer Center - Duarte
1500 East Duarte Road
Duarte, CA 91010
Specialties
Medical Oncology
Education
Medical school:

2017, Doctor of Medicine, State University of New York (SUNY) Downstate Medical School, Brooklyn, New York

Residency:

2017–2020, Internal Medicine Internship and Residency, Donald and Barbara Zucker School of Medicine at Hofstra, Northwell North Shore University and Long Island Jewish Medical Center, Hempstead, New York

Academic Appointments
  • Assistant Professor, Department of Medical Oncology & Therapeutics Research
About Me

Matthew Lee, M.D., MPH, is a medical oncologist at City of Hope® Cancer Center Duarte who specializes in treating lung cancer, including small cell lung cancer. His dedication to personalized, compassionate care is inspired by his own family’s experience with cancer, and he brings that empathy to every patient he treats. 

Dr. Lee earned his medical degree from the State University of New York (SUNY) Downstate Medical School and completed his residency in internal medicine at Hofstra University’s Northwell North Shore University Hospital. He then pursued a fellowship in hematology/oncology at the Albert Einstein College of Medicine/Montefiore Einstein Comprehensive Cancer Center. He also holds a Master of Public Health in Epidemiology, reflecting his strong interest in public health, health disparities and how real-world data can improve care. 

His research explores leading-edge treatments, including targeted therapies, antibody-drug conjugates, immunotherapy, cellular therapies and liquid biopsies (ctDNA) for risk stratification and diagnosis. Dr. Lee is actively involved in several national research groups, including ECOG-ACRIN, ETCTN, the Hoosier Cancer Research Network and the Small Cell Lung Cancer Consortium. 

He has authored more than a dozen peer-reviewed publications, participated in multiple clinical trials and taken part in global health efforts in Thailand, Uganda and Honduras. His work in lung cancer research has earned recognition from the International Association for the Study of Lung Cancer. 

Outside the clinic, Dr. Lee enjoys traveling, experiencing new cultures and cuisines and spending time outdoors running and hiking.

Patient reviews
The patient ratings and comments on this page are obtained from an external Press Ganey® outpatient survey provided to all eligible City of Hope patients within one to two weeks of their treatment occurrence. Raw data from the answers to the survey questions about our physicians are calculated by Press Ganey into a one- to five- star rating. In the spirit of transparency, all patient comments are posted as written by the patient, whether they are positive or negative. We only exclude comments if they are deemed to be slanderous or libelous, contain profanity or vulgar language, or do not relate to the patient's experience with the doctor involved. As a result, the comments are the views and opinions of the patients surveyed and are not endorsed by, and may not necessarily reflect the opinion of, City of Hope.
Feb 4, 2026
5.0
"Excellent doctor [...]. Down to earth, caring. A keeper."
Feb 4, 2026
5.0
"Coordinated like a well oiled machine, lab->doc visit-> infusion . No chaos noted at all. Greatly appreciate physician assistant time which allow doc more time to discuss treatments. 5 Stars for coordination!"
Nov 25, 2025
4.7
"They listen and and respond to my questions and concerns. They treat me with respect and dignity."
Nov 12, 2025
5.0
"Excellent experience, very knowledgeable"
Nov 12, 2025
5.0
"Impressed with the level of coordination among staff and their awareness of my specific issues. They did their preparation, I was treated very well and was overall very impressed."
Nov 5, 2025
5.0
"Dr. Matthew is pleasant, caring, and easy to communicate with. He makes me feel assured with the treatments, and I am in good hands."
Sep 29, 2025
5.0
"The doctor is the best. He is so caring and helpful. Great doctor!!!!!"
Sep 24, 2025
5.0
"Everything was excellent"
Jun 24, 2025
5.0
"All providers exceptional. I wish every cancer patient had this level of care."