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Maria C.B. de Leon,

M.D.

Gynecologic Oncologist

4.9 (249 Ratings)
Biography photo
Location
City of Hope Antelope Valley
44151 15th Street West
Lancaster, CA 93534
City of Hope Mission Hills
15031 Rinaldi Street, Suite 150
Mission Hills, CA 91345
City of Hope Santa Clarita
23823 Valencia Boulevard, Suite 250
Santa Clarita, CA 91355
Specialties
Gynecologic Oncology
Surgery
Education
Medical school:

M.D., University of California Los Angeles, Los Angeles, CA

Residency:

Obstetrics and Gynecology – Yale New Haven Hospital, New Haven, CT

Academic Appointments
  • Assistant Clinical Professor, Division of Gynecologic Oncology, Department of Surgery
About Me

Maria C.B. de Leon, M.D., is an assistant clinical professor of gynecologic oncology in City of Hope’s® Department of Surgery. She sees patients at City of Hope’s clinics in Antelope Valley, Santa Clarita and Mission Hills community sites, ensuring that women diagnosed with cancer receive specialized cancer care closer to home. 

Dr. de Leon earned her bachelor’s degree in biochemistry at the University of California, Davis, then went on to receive her medical degree from the University of California, Los Angeles. She completed her residency in obstetrics and gynecology at Yale-New Haven Hospital in Connecticut, where she received recognition for excellence in laparoscopic surgery. Following her residency, she completed her fellowship in gynecologic oncology at Indiana University in Bloomington. 

In addition to her clinical work, Dr. de Leon is actively involved in several professional organizations, including serving on the Statistics Subcommittee of the Gynecologic Oncology Fellow Research Network and being a member of the Society of Gynecologic Oncology, the American Association of Gynecologic Laparoscopists and the American College of Obstetricians and Gynecologists. She has received several awards, including Indiana University’s Simon Cancer Travel Award. 

Fluent in Spanish, Tagalog, and Ilocano, Dr. de Leon is committed to delivering compassionate, care to the diverse communities she serves.

Patient reviews
The patient ratings and comments on this page are obtained from an external Press Ganey® outpatient survey provided to all eligible City of Hope patients within one to two weeks of their treatment occurrence. Raw data from the answers to the survey questions about our physicians are calculated by Press Ganey into a one- to five- star rating. In the spirit of transparency, all patient comments are posted as written by the patient, whether they are positive or negative. We only exclude comments if they are deemed to be slanderous or libelous, contain profanity or vulgar language, or do not relate to the patient's experience with the doctor involved. As a result, the comments are the views and opinions of the patients surveyed and are not endorsed by, and may not necessarily reflect the opinion of, City of Hope.
Mar 31, 2026
5.0
"Couldn't ask for a better doctor"
Mar 24, 2026
5.0
"Excellent"
Mar 24, 2026
5.0
"All good"
Mar 18, 2026
5.0
"Not fully understood what complications factors would be involved after procedure."
Mar 17, 2026
5.0
"Very well pleased"
Mar 10, 2026
5.0
"Top notch performance. Will recommend."
Mar 10, 2026
5.0
"All did a wonderful job"
Feb 19, 2026
5.0
"Would refer any of my friends or family to this doctor, and caring staff."
Feb 19, 2026
5.0
"Dr. De Leon is always an excellent listener, and a great communicator in explaining all procedures, and health questions to me."
Feb 17, 2026
5.0
"Very good"
Feb 17, 2026
5.0
"Dr was gentle and careful. I felt she heard my concerns."
Feb 13, 2026
5.0
"Good"
Feb 5, 2026
5.0
"I was very satisfied and pleased with this care provider. She was polite, friendly efficient, and very informative.!"
Feb 3, 2026
5.0
"I will always recommend Dr Maria De Leon to anyone needing an oncologist"
Jan 21, 2026
5.0
"Excellent"
Jan 21, 2026
5.0
"Very professional and their assistance with me, went very well"
Jan 8, 2026
5.0
"Good"
Jan 8, 2026
5.0
"Good"
Jan 6, 2026
5.0
"I would recommend"
Dec 20, 2025
5.0
"She great"
Oct 24, 2025
5.0
"Dr. De Leon is very professional and thorough. [...]"
Oct 23, 2025
5.0
"Dr DeLeon is great, has been with me since the start"
Oct 17, 2025
5.0
"Love City of Hope people"
Sep 28, 2025
5.0
"I would definitely recommend the Doctor to all my family, friends and acquaintances."
Sep 26, 2025
5.0
"Good.."
Sep 25, 2025
4.7
"Good"
Sep 25, 2025
4.7
"Overall good!"
Sep 21, 2025
4.7
"I felt like I was lucky to have her and I was in good hands."
Sep 11, 2025
5.0
"If I would recommend it"
Sep 11, 2025
5.0
"Very good experience. Thank you"
Sep 4, 2025
5.0
"Excellent"
Aug 24, 2025
2.7
"She just said the cyst was probably nothing to worry about and I would not have to see her again because it hadn't grown since 2015. How would she know how long I had it? I didn't know and Even my oncologist never discussed it with me if he knew."
Aug 14, 2025
5.0
"Good"
Aug 14, 2025
5.0
"Very good"
Aug 12, 2025
5.0
"Provider excellent"
Aug 12, 2025
5.0
"My overall experience was very excellent!!ALL AREAS WERE ABOVE AVERAGE!!!"
Aug 11, 2025
5.0
"Good experience"
Aug 11, 2025
5.0
"Good experience"
Aug 11, 2025
5.0
"Good experience"
Jul 25, 2025
5.0
"Good experience"
Jul 25, 2025
5.0
"Good experience"
Jul 22, 2025
3.2
"[...] the appointment seems very rushed. She was nice and did explain the process but was very fast. By the time I finished seeing her, I had additional questions and concerns [...]"
Jul 20, 2025
5.0
"Dr. De Leon is an exceptional physician. Very empathetic, caring and truly cares about her patients. I would and do recommend her to whomever needs an oncologist."
Jul 10, 2025
5.0
"The Best Ever!!!"
Jul 10, 2025
5.0
"Dr. DeLeon & her whole team were the best ever!!! Thank y'all"
Jul 10, 2025
5.0
"Your high on my list to recommend top notch doctors and Hospital"
Jul 10, 2025
5.0
"Have recommended Dr Maria De Leon to others. She's the sweetest and compassionate doctor. Love her"
Jun 24, 2025
2.5
"Dr. De Leon is an excellent Dr. She just doesn't listen to me and try and push chemo and radiation. The sarcoma I have is resistant to chemo."
Jun 18, 2025
5.0
"The staff at all facilities visited have been delightful."
Jun 6, 2025
5.0
"Excellent"
Jun 6, 2025
5.0
"Excellent"
May 26, 2025
5.0
"I wish Dr De Leon specialized in other area of medicine. She is amazing and I'd love to see her for everything."
May 26, 2025
5.0
"I had to call the after hours number when I was in the ER and Dr DeLeon not only answered but I also felt she was empathetic to my situation and very helpful with getting me the treatment I needed. She worked with the ER doctor and informed him of her recommend course of treatment. I am truly grateful for her compassion and professionalism."