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Maria C.B. de Leon,

M.D.

Gynecologic Oncologist

4.9 (230 Ratings)
Biography photo
Location
City of Hope Antelope Valley
44151 15th Street West
Lancaster, CA 93534
City of Hope Mission Hills
15031 Rinaldi Street, Suite 150
Mission Hills, CA 91345
City of Hope Santa Clarita
23823 Valencia Boulevard, Suite 250
Santa Clarita, CA 91355
Specialties
Gynecologic Oncology
Surgery
Education
Medical school:

M.D., University of California Los Angeles, Los Angeles, CA

Residency:

Obstetrics and Gynecology – Yale New Haven Hospital, New Haven, CT

Academic Appointments
  • Assistant Clinical Professor, Division of Gynecologic Oncology, Department of Surgery
About Me

Maria C.B. de Leon, M.D., is an assistant clinical professor of gynecologic oncology in City of Hope’s® Department of Surgery. She sees patients at City of Hope’s clinics in Antelope Valley, Santa Clarita and Mission Hills community sites, ensuring that women diagnosed with cancer receive specialized cancer care closer to home. 

Dr. de Leon earned her bachelor’s degree in biochemistry at the University of California, Davis, then went on to receive her medical degree from the University of California, Los Angeles. She completed her residency in obstetrics and gynecology at Yale-New Haven Hospital in Connecticut, where she received recognition for excellence in laparoscopic surgery. Following her residency, she completed her fellowship in gynecologic oncology at Indiana University in Bloomington. 

In addition to her clinical work, Dr. de Leon is actively involved in several professional organizations, including serving on the Statistics Subcommittee of the Gynecologic Oncology Fellow Research Network and being a member of the Society of Gynecologic Oncology, the American Association of Gynecologic Laparoscopists and the American College of Obstetricians and Gynecologists. She has received several awards, including Indiana University’s Simon Cancer Travel Award. 

Fluent in Spanish, Tagalog, and Ilocano, Dr. de Leon is committed to delivering compassionate, care to the diverse communities she serves.

Patient reviews
The patient ratings and comments on this page are obtained from an external Press Ganey® outpatient survey provided to all eligible City of Hope patients within one to two weeks of their treatment occurrence. Raw data from the answers to the survey questions about our physicians are calculated by Press Ganey into a one- to five- star rating. In the spirit of transparency, all patient comments are posted as written by the patient, whether they are positive or negative. We only exclude comments if they are deemed to be slanderous or libelous, contain profanity or vulgar language, or do not relate to the patient's experience with the doctor involved. As a result, the comments are the views and opinions of the patients surveyed and are not endorsed by, and may not necessarily reflect the opinion of, City of Hope.
Jul 16, 2026
5.0
"I recomeded friends and family."
Jul 16, 2026
5.0
"Very caring"
Jun 18, 2026
5.0
"I have a deep admiration for the staff and volunteers associated with caring for the patients. It's always refreshing and uplifting to see and hear the staff being professional and joking at times with each other. I enjoy coming to the clinic."
Jun 16, 2026
5.0
"Dr DeLeon is so awesome and very helpful so knowledgeable and easy to talk to"
Jun 9, 2026
5.0
"Dr. DeLeon is a great dr. Kind and compassionate. I would highly recommend her to anyone."
Jun 9, 2026
5.0
"I would highly recommend City of Hope. Everyone is kind and helpful."
Jun 4, 2026
5.0
"I recommend it to anyone, very efficient and very friendly staff, very good service."
Jun 4, 2026
5.0
"I would have liked to, if he had talked to me if there are other options, and the risks of that treatment."
May 25, 2026
5.0
"I was so impressed by staff and Drs in communication, friendlyness, knowledge, care."
May 23, 2026
5.0
"Visit went well."
May 23, 2026
5.0
"She is very knowledgeable n I trust her."
May 19, 2026
5.0
"Very nice"
May 19, 2026
5.0
"She is an excellent surgeon and a wonderful person. I would recommend her to anyone."
May 19, 2026
4.7
"Everybody only care team is on point"
May 19, 2026
4.7
"Dr DeLeon is always very thorough in explanation of pathology, procedures and necessary coming treatment"
May 12, 2026
5.0
"I HAVE recommended COH to others & when my neighbor was referred by her dr I have told her " I am sorry this is happening but you are in good hands"."
May 3, 2026
5.0
"They are authentic. Genuinely caring."
Apr 23, 2026
5.0
"ALWAYS GOOD."
Apr 15, 2026
5.0
"All good"
Apr 15, 2026
5.0
"Very good experience."
Apr 15, 2026
5.0
"All good"
Mar 31, 2026
5.0
"Couldn't ask for a better doctor"
Mar 24, 2026
5.0
"All good"
Mar 24, 2026
5.0
"Excellent"
Mar 18, 2026
5.0
"Not fully understood what complications factors would be involved after procedure."
Mar 17, 2026
5.0
"Very well pleased"
Mar 10, 2026
5.0
"Top notch performance. Will recommend."
Mar 10, 2026
5.0
"All did a wonderful job"
Feb 19, 2026
5.0
"Would refer any of my friends or family to this doctor, and caring staff."
Feb 19, 2026
5.0
"Dr. De Leon is always an excellent listener, and a great communicator in explaining all procedures, and health questions to me."
Feb 17, 2026
5.0
"Very good"
Feb 17, 2026
5.0
"Dr was gentle and careful. I felt she heard my concerns."
Feb 13, 2026
5.0
"Good"
Feb 5, 2026
5.0
"I was very satisfied and pleased with this care provider. She was polite, friendly efficient, and very informative.!"
Feb 3, 2026
5.0
"I will always recommend Dr Maria De Leon to anyone needing an oncologist"
Jan 21, 2026
5.0
"Excellent"
Jan 21, 2026
5.0
"Very professional and their assistance with me, went very well"
Jan 8, 2026
5.0
"Good"
Jan 8, 2026
5.0
"Good"
Jan 6, 2026
5.0
"I would recommend"
Dec 20, 2025
5.0
"She great"
Oct 24, 2025
5.0
"Dr. De Leon is very professional and thorough. [...]"
Oct 23, 2025
5.0
"Dr DeLeon is great, has been with me since the start"
Oct 17, 2025
5.0
"Love City of Hope people"
Sep 28, 2025
5.0
"I would definitely recommend the Doctor to all my family, friends and acquaintances."
Sep 26, 2025
5.0
"Good.."
Sep 25, 2025
4.7
"Good"
Sep 25, 2025
4.7
"Overall good!"