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Luke Chen,

M.D.

Medical Oncologist and Hematologist

4.9 (264 Ratings)
Biography photo
Location
City of Hope Orange County Lennar Foundation Cancer Center
1000 Five Point
Irvine, CA 92618
City of Hope Seacliff
2100 Main Street #300
Huntington Beach, CA 92648
Specialties
Hematologic Oncology
Medical Oncology
Education
Medical school:
  • 1998, M.D., University of California San Diego School of Medicine, La Jolla, California
  • 1993, Bachelor of Arts, Molecular Cell Biology, University of California Berkeley, California
Residency:
  • 1998–2001, Internal Medicine, University of California Irvine, Irvine, California
Academic Appointments
  • Assistant Clinical Professor, Department of Medical Oncology & Therapeutics Research
About Me

Luke Chen, M.D., is a medical oncologist and hematologist at City of Hope® Orange County Lennar Foundation Cancer Center, where he works daily to help patients fight a wide range of cancer types and manage their quality of life. Inspired daily by their strength and resilience, Dr. Chen encourages his patients to stay hopeful, reminding them that today’s cancer care options include many effective and well-tolerated treatments. 

Dr. Chen received his medical degree from the University of California (UC), San Diego, then completed his internal medicine residency and hematology/oncology fellowship at UC Irvine. Over the years, he has taken part in research aimed at advancing treatment for prostate cancer and other serious diseases and has published educational studies on rare forms of tuberculosis, some of which are used in an academic setting at UC San Diego. 

When he's not seeing patients or working on research, Dr. Chen enjoys relaxing in the garden and spending time with his wife and two sons. He is fluent in Mandarin.

Patient reviews
The patient ratings and comments on this page are obtained from an external Press Ganey® outpatient survey provided to all eligible City of Hope patients within one to two weeks of their treatment occurrence. Raw data from the answers to the survey questions about our physicians are calculated by Press Ganey into a one- to five- star rating. In the spirit of transparency, all patient comments are posted as written by the patient, whether they are positive or negative. We only exclude comments if they are deemed to be slanderous or libelous, contain profanity or vulgar language, or do not relate to the patient's experience with the doctor involved. As a result, the comments are the views and opinions of the patients surveyed and are not endorsed by, and may not necessarily reflect the opinion of, City of Hope.
Apr 1, 2026
5.0
"The best"
Mar 22, 2026
2.8
"Maybe Dr. Chen had an off day; he is human. [...] We know Dr. Chen is technically sound & a popular Medical Oncologist. His bedside manner though was poor, which surprised us. [...]"
Mar 20, 2026
2.8
"Find it hard to get Dr's recommendation. On issues where there's not a clear direction or urgent problem, he won't give me a medical recommendation. He gives me options and leaves treatment decisions to me rather than tell me what he thinks I should do. I mean he's the doctor. I don't feel like I should be the one determining the best treatment path."
Mar 14, 2026
5.0
"Professional"
Mar 14, 2026
5.0
"Top level"
Mar 2, 2026
5.0
"Dr. Chen is always wonderful!! He's concerned, thorough and easy to talk to."
Feb 21, 2026
5.0
"[...] Dr Chen is THE BEST!"
Feb 19, 2026
5.0
"Good"
Feb 19, 2026
5.0
"Good"
Feb 19, 2026
5.0
"We really liked Dr. Chen!"
Feb 10, 2026
5.0
"I must point out that Dr. Chen leads an exceptional team providing care for me. I do not see Dr. Chen directly often, but I have every reason to believe that he is always on top of my case and I am pleased with how well his exceptional team work together to provide me the best possible care."
Jan 23, 2026
5.0
"I'm always pleased with how Dr. Chen advises me and evaluate my condition. He's number one doctor for me."
Jan 20, 2026
5.0
"Good"
Jan 20, 2026
5.0
"Good"
Jan 14, 2026
5.0
"Dr Chen explains questions I have with clear answers. I feel fortunate he is my oncologist."
Dec 27, 2025
5.0
"All Excellent ."
Nov 27, 2025
5.0
"Excellent service"
Nov 22, 2025
5.0
"All good"
Nov 19, 2025
5.0
"I am extremely grateful to have the COH facility [...]. It has made this entire process so much easier."
Nov 19, 2025
5.0
"Dr Chen has been a great resource of Information and care for over 4 years. He is great and appreciated."
Nov 18, 2025
5.0
"Dr. Luke Chen was friendly, polite and knowledgeable. He took the time to explain everything clearly and throughly. He answered my questions in an easy-to-understand manner."
Nov 7, 2025
5.0
"Staff is great! [...]"
Nov 5, 2025
5.0
"Dr. Chen was excellent in every way"
Oct 19, 2025
5.0
"Dr. Luke Chen is one of the best doctors I've had the pleasure to work with."
Oct 16, 2025
5.0
"All demonstrated they were on the same page."
Oct 16, 2025
5.0
"No one wants to have to see an oncologist COH offices represent how all dr's offices and assistants should look and provide patient care."
Sep 20, 2025
5.0
"Good"
Sep 20, 2025
5.0
"Good"
Sep 19, 2025
5.0
"Dr. Chen is excellent with his part of care. [...]"
Sep 19, 2025
5.0
"Solid recommendation for treatment"
Sep 17, 2025
5.0
"Exceptional physician who showed comfort and compassion along with excellent information for my diagnosis."
Sep 8, 2025
5.0
"The staff are always kind and efficient."
Sep 8, 2025
5.0
"Dr Chen is a caring doctor. He explained things in an easy to understand way. I would highly recommend him to others."
Aug 27, 2025
5.0
"Dr Luke Chen is a 5+ star doctor. His caring and gentle demeanor is so rare. He shows genuine concern and listens with a caring heart."
Aug 23, 2025
4.9
"Very knowledgeable"
Jul 30, 2025
5.0
"Nice person"
Jul 25, 2025
5.0
"Good"
Jul 25, 2025
5.0
"Good"
Jul 25, 2025
5.0
"Very good"
Jul 19, 2025
5.0
"Good"
Jul 10, 2025
5.0
"Treatment by professionals and staff at City of Hope far exceed those of any other medical facility I've visited."
Jun 29, 2025
5.0
"Dr. Chen is always making sure that I understand what he is telling me about my health. Very good doctor."
Jun 26, 2025
5.0
"Incredibly professional, efficient and very friendly and nice staffs"
Jun 26, 2025
5.0
"Dr Chen is always really nice, kind, and professional"
Jun 26, 2025
5.0
"A good team !"
Jun 26, 2025
5.0
"Dr Chen is the best, very attentive, concerned about my health and always making sure I understand and follow the instructions. I appreciate the attention and care, I recommend it 1000%"