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Karen Tsai,

M.D.

Endocrinologist

4.8 (167 Ratings)
Biography photo
Location
City of Hope Duarte
1500 East Duarte Road
Duarte, CA 91010
Specialties
Diabetes, Endocrinology and Metabolism
Education
Medical school:

2017, Doctor of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY

Residency:

2020, Internal Medicine, University of Southern California, Los Angeles, CA

Academic Appointments
  • Assistant Clinical Professor, Department of Diabetes, Endocrinology & Metabolism
About Me

Karen Tsai, M.D., is an endocrinologist who values collaboration and personalized care. At City of Hope® Cancer Center Duarte, she collaborates with a multidisciplinary team to create individualized treatment plans that address unique patient needs — especially those facing rare or complex conditions. 

Dr. Tsai’s clinical and research interests center on onco-endocrinology, or endocrine diseases resulting from cancer immunotherapy. She specializes in thyroid disorders, with special interest in thyroid cancers, endocrine disorders from cancer immunotherapy and targeted therapy treatments, as well as diabetes. 

A Southern California native, Dr. Tsai earned her medical degree at the Renaissance School of Medicine at Stony Brook University in New York. She completed her internal medicine residency at the University of Southern California (USC) and her endocrinology fellowship at the University of California Los Angeles (UCLA). She also graduated magna cum laude and Phi Beta Kappa from USC with a bachelor's degree in biological sciences.

Patient reviews
The patient ratings and comments on this page are obtained from an external Press Ganey® outpatient survey provided to all eligible City of Hope patients within one to two weeks of their treatment occurrence. Raw data from the answers to the survey questions about our physicians are calculated by Press Ganey into a one- to five- star rating. In the spirit of transparency, all patient comments are posted as written by the patient, whether they are positive or negative. We only exclude comments if they are deemed to be slanderous or libelous, contain profanity or vulgar language, or do not relate to the patient's experience with the doctor involved. As a result, the comments are the views and opinions of the patients surveyed and are not endorsed by, and may not necessarily reflect the opinion of, City of Hope.
Jul 22, 2026
5.0
"Excellent staff in all departments that I have visited. The people in the labs are so efficient, the imaging department is full of kind people,"
Jul 22, 2026
5.0
"I have already given Dr TSAI's information to a friend [...]"
Jul 21, 2026
5.0
"Dr. Karen Tsai is one of the best physicians I have ever had. She is incredibly thorough, compassionate, and attentive in her care. She takes the time to listen carefully to my concerns, address all of my questions, and ensure I fully understand my treatment options. Her genuine dedication to her patients and commitment to providing exceptional care consistently make me feel valued, supported, and confident in my healthcare decisions."
Jul 16, 2026
5.0
"Very good"
Jul 16, 2026
5.0
"Very pleasant"
Jul 14, 2026
5.0
"Best"
Jul 9, 2026
5.0
"She is the best dr I have ever had. She is very thorough, kind and smart"
Jul 6, 2026
3.1
"Since my first visit with This doctor, I had a hard time keeping up as she talks extremely fast. The second visit I brought my husband along, so I didn't miss any instructions. I really wanted to talk more about a liver issue and the connection between that and my diabetes"
Jul 6, 2026
5.0
"Excellent dra"
Jul 6, 2026
5.0
"Highly recommended, super friendly, all the staff"
Jul 3, 2026
5.0
"I credit this doctor with total reversal of my diabetic condition. I am grateful to her every day."
Jun 30, 2026
5.0
"Very knowledgeable and caring for my overall health"
Jun 26, 2026
5.0
"Dr. Tsai is an exceptionally caring and compassionate physician. Despite her busy schedule, she took the time to personally contact my pharmacy to authorize and refill my medications. She also carefully reviewed my medications and made thoughtful recommendations to ensure I received the best possible care. I have also witnessed her kind, respectful, and compassionate interactions with other patients. Her professionalism and genuine concern for her patients are truly outstanding. I highly recommend Dr. Tsai to my family, friends, and anyone seeking an excellent physician."
Jun 26, 2026
5.0
"Dr. Is very knowledgeable and listened carefully to my medical history"
Jun 25, 2026
5.0
"Very professional"
Jun 25, 2026
5.0
"Very helpful listen to you regarding concerns"
Jun 21, 2026
5.0
"Dr. Tsai is an exceptional physician."
Jun 16, 2026
5.0
"Good."
Jun 16, 2026
5.0
"The doctor is compassionate and efficient."
Jun 16, 2026
5.0
"Good"
Jun 16, 2026
5.0
"Good"
Jun 16, 2026
5.0
"Good"
Jun 10, 2026
5.0
"10 star."
Jun 6, 2026
5.0
"Dr Tsai is always very helpful"
Jun 6, 2026
5.0
"Dr. Tsai always showed care and explained well"
Jun 4, 2026
5.0
"I enjoy and am quite comfortable with Dr. Tsai. She is knowledgeable and individualizes my care."
Jun 4, 2026
5.0
"Excellent"
Jun 4, 2026
5.0
"Excellent"
Jun 4, 2026
5.0
"Excellent"
May 8, 2026
5.0
"Wonderful experience"
May 8, 2026
5.0
"Great experience"
May 7, 2026
5.0
"Dr. Tsai is fantastic. She is quick to follow up on issues and I trust her opinion."
May 4, 2026
5.0
"Dr. Tsai is very thorough and explains to me any concerns I may have"
Apr 7, 2026
5.0
"Dr. Tsai is the only doctor that I know always checks all my meds. She personally follows up and will call to check something or tell me something. Maybe she has more time than my other Dr.s. I don't know. She Is very thorough."
Mar 31, 2026
5.0
"This provider speaks extremely rapidly and seems in a rush."
Mar 26, 2026
5.0
"Dr Tsai is great. Always helpful . On top of all my condition and lab results"
Mar 25, 2026
5.0
"It was a smooth visit as it always is."
Mar 25, 2026
5.0
"I have recently recommended a friend to Dr Tsai [...]"
Mar 19, 2026
5.0
"Dr. Tsai is easy to communicate with, and clearly is concerned with my health and well-being. One of the best doctors I've had the privilege of being associated with. Dr. Tsai is GREAT"
Mar 19, 2026
5.0
"Dr. Tsai is a very kind and caring physician. We are blessed to have her taking care my mom problems."
Mar 15, 2026
5.0
"Dr Tsai is always thorough and goes over everything in great detail."
Mar 7, 2026
5.0
"We had no issues The experience was great.."
Mar 7, 2026
5.0
"Dr Tsai , She is very efficient in responding to all our questions and concerns. She's very professional in all what she does appreciate her greatly"
Mar 4, 2026
5.0
"[...] Dr Tsai is an awesome knowledgeable provider."
Mar 4, 2026
5.0
"City of Hope is the City of HOPE, that brings Hope to others. [...]"
Mar 2, 2026
5.0
"Dr. Tsai very carefully reviewed with me the results of the blood work she had ordered. During the visit she took note of my feet and commented how the swelling had gone down. I shared how an outside cardiologist had changed my medications and those changes had reduced the swelling and my fatigue. Good discussion followed. Dr. Tsai treats my whole person very well."
Mar 2, 2026
5.0
"Dr. Tsai appears to run a tight ship. Everything done well and in order. Her staff has always been very kind and considerate. Probably her staff simply follows her excellent example. Dr. Tsai reminds me of my first gynecologist who had been trained in Scotland. She treated the whole person and not just presenting symptoms. Dr. Tsai appears to do the same with me and that is very good."
Feb 20, 2026
5.0
"Very thorough and answered all my questions. And kept asking if I had any other questions which was nice"
Feb 19, 2026
5.0
"Dr. Tsai was incredibly thorough and explained everything in a way I could understand."
Feb 19, 2026
5.0
"Excellent care and concern"
Feb 14, 2026
5.0
"Dr Tsai is great"
Feb 2, 2026
5.0
"Very good"
Dec 20, 2025
5.0
"Dr Tsai is one of the best doctors I've seen"
Dec 5, 2025
5.0
"Very easy to speak to Dr. Tsai (with video technology and in general) I felt she asked great questions and listened to my answers."
Dec 5, 2025
5.0
"Dr. Tsai is wonderful! I was so impressed with her genuine interest in helping me and gathering information. She exceeded my expectations in ever way and I would highly recommend her."
Dec 5, 2025
5.0
"Great Doctor"
Dec 4, 2025
5.0
"Dr Tsai is great. Always has time and answers all my questions"
Dec 2, 2025
5.0
"I recommend my doctor and assistant to anybody who needed an endocrinologist."
Nov 21, 2025
5.0
"Always have excellent experience with Dr. Tsai"
Nov 21, 2025
5.0
"Very good"
Oct 23, 2025
5.0
"Dr Tsai is great [...]"
Oct 17, 2025
5.0
"It is important to me as a patient that I understand my disease and treatments in order to provide myself support and care. I love learning. Dr. Tsai went beyond my expectations. I can now make clear and knowledgeable decision around treatment regarding risks, medication and all my options."
Oct 5, 2025
5.0
"Dr. Tsai was very informative and explained my condition and the process very thoroughly. I appreciated the time she spent with me to explain things in great detail."
Sep 27, 2025
5.0
"Dr. Tsai is very easy to speak to and listens very well."
Sep 26, 2025
3.9
"She looks at me very little. Always on the computer"
Sep 24, 2025
5.0
"I love my doctor,Karen Tsai. She is so attentive and kind. She never rushes me, explains clearly and patiently. She is amazing snd I feel lucky to have found her."
Sep 24, 2025
1.3
"This doctor was clearly in a rush. [...] She talked very fast. She asked questions that I already had filled out in my many surveys. She didn't know about big things in my health history. She didn't show any care about my concerns. She seemed dismissive because my health issues were small, but it's not my fault I was told to see an endocrinologist. I was hoping to get more help, guidance on my thyroid issues. She once again talked very fast and had no care."