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George Bernard Semeniuk, III,

M.D.

Medical Oncologist and Hematologist

4.9 (233 Ratings)
Biography photo
Location
City of Hope Newport Beach
1601 Avocado Avenue
Newport Beach, CA 92660
City of Hope Orange County Lennar Foundation Cancer Center
1000 Five Point
Irvine, CA 92618
Specialties
Hematologic Oncology
Education
Medical school:
  • M.D., St. Georges University School of Medicine, Great River, NY
Residency:
  • Residency, University of California San Francisco, Oakland, CA
Academic Appointments
  • Clinical Professor, Department of Medical Oncology & Therapeutics Research
About Me

George B. Semeniuk, III, M.D., was inspired to pursue oncology during medical school, following the loss of a young family member to brain cancer. With over 20 years of experience in cancer care, he remains committed to developing customized treatment strategies that reflect the unique needs and circumstances of every patient and their loved ones. He is a board-certified medical oncologist and hematologist and a clinical professor in the Department of Medical Oncology and Therapeutics Research at City of Hope® Cancer Center Duarte

Dr. Semeniuk is known for his compassionate and attentive approach, as well as his collaborative philosophy of care, working with patients and their care team to create treatment plans that align with their personal goals and values. His clinical focus includes head and neck cancers, lung cancer and skin cancer. In the research lab, Dr. Semeniuk supports research efforts at City of Hope that are focused on developing and testing new cancer therapies. With training in integrative oncology, he blends evidence-based complementary approaches with conventional treatments to support each patient physically, emotionally and spiritually. 

Dr. Semeniuk earned his medical degree from St. George’s University in New York. He completed his internal medicine internship and residency at the University of California, San Francisco, where he also served as chief resident, as well as fellowships in both hematology/oncology at the University of Texas Southwestern Medical Center in Dallas and integrative medicine at the University of Arizona in Tucson. Prior to joining City of Hope, Dr. Semeniuk ran a private practice and held positions at Hoag Memorial Hospital Presbyterian Hospital in Newport Beach, California, and the Keck School of Medicine at the University of Southern California in Los Angeles. 

Outside of the clinic, Dr. Semeniuk enjoys spending time with his family, playing golf and tennis, hiking, cooking and seeking out new adventures.

Patient reviews
The patient ratings and comments on this page are obtained from an external Press Ganey® outpatient survey provided to all eligible City of Hope patients within one to two weeks of their treatment occurrence. Raw data from the answers to the survey questions about our physicians are calculated by Press Ganey into a one- to five- star rating. In the spirit of transparency, all patient comments are posted as written by the patient, whether they are positive or negative. We only exclude comments if they are deemed to be slanderous or libelous, contain profanity or vulgar language, or do not relate to the patient's experience with the doctor involved. As a result, the comments are the views and opinions of the patients surveyed and are not endorsed by, and may not necessarily reflect the opinion of, City of Hope.
Mar 19, 2026
5.0
"Listen to my problems and made appointments for tests [...]"
Mar 19, 2026
5.0
"Contact me a few times to be sure I got the appointments [...]"
Feb 21, 2026
5.0
"helpful, friendly in every way"
Feb 13, 2026
5.0
"I recommend this provider 200% outstanding care knowledge and kindness"
Feb 13, 2026
5.0
"Absolutely a fantastic experience and will recommend City of Hope and staff to all my friends family etc"
Feb 6, 2026
5.0
"Dr. Semeniuk is very professional, knowledgeable of my condition and thorough in our consultations."
Feb 6, 2026
5.0
"Excellent!!!"
Feb 6, 2026
5.0
"Excellent doctor and staff and service."
Jan 22, 2026
5.0
"Dr. Semeniuk is my doctor for life!!"
Jan 20, 2026
5.0
"In any case, I recommend this hospital for its treatment, which is what cures the sick, and then for all its studies and doctors that make this Hospital the best"
Jan 20, 2026
5.0
"Dr. Semeniuk is a very dedicated professional, he listens and supports his patients and other colleagues, sharing diagnoses and opinions, he has a lot of human quality as a doctor, I love to see him always"
Jan 14, 2026
5.0
"Dr Semeniuk is the VERY BEST! He has saved my life several times since my cancer returned with a vengeance in 2018."
Dec 20, 2025
5.0
"My wife and I have been patients of Dr. George Semeniuk for well over 10 years, and we would not go to any other oncologist/hematologist unless Dr. Semeniuk referred us!"
Nov 15, 2025
5.0
"I have recommended him, and person is now his patient."
Nov 15, 2025
5.0
"I have told many people how impressive your staff and facility are, from valets, fromt desk, wheelchair service, labs, to exam rooms and doctors."
Sep 19, 2025
5.0
"My doctor is crucial to my maintaining my good health!"
Sep 10, 2025
5.0
"Dr Semeniuk, his PA, and nursing staff clerks are all excellent. [...]"
Aug 16, 2025
5.0
"Excellent longtime physician-knowledgable and caring, dedicated"
Aug 13, 2025
5.0
"Excellent listener, very empathetic."
Aug 2, 2025
5.0
"Highly recommended"
Aug 2, 2025
5.0
"I always recommend them to my acquaintances"
Aug 1, 2025
5.0
"Excellent physician in every way"
Aug 1, 2025
5.0
"Provider is A++++. I have been with him for years. I have to go to several physicians to deal with what is wrong with. Specifically, polycythemia and cardio are my primary problems. He has given me excellent referrals [...] He has always been my preferred provider and will be as long as I am alive. You are very lucky to have him."
Jun 11, 2025
5.0
"Dr Semeniuk is the best! He has saved my life several times and seen me through some of the darkest days of my journey. He always cares and listens to my concerns and we work to solve a problem together. He is a fabulous oncologist & a wonderful asset to City Of Hope!"