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Charles B. Nguyen,

M.D.

Medical Oncologist

4.9 (161 Ratings)
Biography photo
Location
City of Hope Orange County Lennar Foundation Cancer Center
1000 Five Point
Irvine, CA 92618
Specialties
Medical Oncology
Genitourinary Oncology
Education
Medical school:
  • 2018, Doctor of Medicine, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma
Residency:
  • 2018–2021, Internal Medicine, Baylor College of Medicine, Houston, Texas
Academic Appointments
  • Assistant Clinical Professor, Department of Medical Oncology & Therapeutics Research
About Me

Charles B. Nguyen, M.D., is a medical oncologist at City of Hope® Orange County Lennar Foundation Cancer Center. Dr. Nguyen specializes in treating cancers of the genitourinary system, including kidney, bladder and prostate cancer. He is passionate about bringing the latest research and treatments to his patients through clinical trials, including the phase 2 FORTUNE study in non-clear cell kidney cancer. 

In his research work, Dr. Nguyen works to understand how cancer behaves at a genetic level, with the goal of personalizing care and improving outcomes. His work has been published in top medical journals such as the Journal of Clinical Oncology Precision Oncology and he has presented his findings at major cancer conferences including the American Society of Clinical Oncology. 

Dr. Nguyen earned his medical degree at the University of Oklahoma in Norman, then completed his internal medicine residency at Baylor College of Medicine in Houston, Texas. He completed his training with a hematology-oncology fellowship at the University of Michigan in Ann Arbor. He has received multiple awards and is a member of the Gold Humanism Honor Society, which recognizes doctors who treat patients with compassion and respect. He speaks fluent Vietnamese.

Patient reviews
The patient ratings and comments on this page are obtained from an external Press Ganey® outpatient survey provided to all eligible City of Hope patients within one to two weeks of their treatment occurrence. Raw data from the answers to the survey questions about our physicians are calculated by Press Ganey into a one- to five- star rating. In the spirit of transparency, all patient comments are posted as written by the patient, whether they are positive or negative. We only exclude comments if they are deemed to be slanderous or libelous, contain profanity or vulgar language, or do not relate to the patient's experience with the doctor involved. As a result, the comments are the views and opinions of the patients surveyed and are not endorsed by, and may not necessarily reflect the opinion of, City of Hope.
Mar 28, 2026
"Dr. Nguyen is top notch! He explains everything in a way that's easy to understand. He is very easy to talk to and you can tell he cares about your care plan. Highly recommended!"
Feb 18, 2026
5.0
"MD Nguyen. Excellent physician, in all ways"
Feb 18, 2026
5.0
"Wonderfull in everyway, very happy in all they do"
Feb 17, 2026
5.0
"Excellent!"
Feb 10, 2026
5.0
"Your facility, doctors and nurses are outstanding! Thank you for your service!"
Feb 10, 2026
5.0
"The only one thing, I wish we started radiation long time ago on some of the large metastases, if we did a Pet scan earlier. That's the only regret I have about proposed treatment."
Jan 13, 2026
5.0
"All great"
Jan 10, 2026
5.0
"Doctors and support people at City of Hope are always caring and very professional...."
Jan 9, 2026
5.0
"The care at City of Hope the best!"
Jan 2, 2026
5.0
"I have I haven't had any bad experiences with the provider"
Dec 23, 2025
5.0
"Good"
Dec 23, 2025
5.0
"Good"
Dec 23, 2025
5.0
"Good"
Nov 23, 2025
5.0
"Dr Nguyen is fantastic, helpful, exceptionally intelligent"
Nov 2, 2025
5.0
"I think COH is wonderful institution, perhaps the best of its kind I have ever experienced. I cannot say enough about the people, the service and the help I have received. COH Orange County is just a wonderful place."
Oct 10, 2025
5.0
"They are the best and very professional."
Oct 10, 2025
5.0
"Very Professional and caring, listen to my concerns."
Oct 10, 2025
5.0
"Excellent All staff is very knowledgeable and professional. During infusion sessions I was always given numerous suggestions to manage various side effects that really helped. Very empathetic and supportive."
Oct 10, 2025
5.0
"Stroke of luck that I had Dr. Nguyen to guide my care. From the very first meeting explained my situation in detail and my options. The treatment has worked! I'm fortunate and grateful. Dr Nguyen clearly very knowledgeable and aware of treatment options. His confidence always helped boost my morale"
Oct 4, 2025
5.0
"Dr Nguyen was very helpful in explaining my condition and treatment."
Sep 12, 2025
4.9
"Good"
Sep 12, 2025
4.9
"Good"
Aug 12, 2025
4.9
"Flawless"
Aug 1, 2025
4.9
"He's the best he listens and puts my mind at ease"
Aug 1, 2025
5.0
"All excellent"
Jul 12, 2025
5.0
"Great experience"
Jul 12, 2025
5.0
"Excellent care from everyone on my care team, including receptionist and staff personnel"
Jul 8, 2025
5.0
"Dr. Charles Nguyen is one of the best. He has excellent social and medical treatment knowledge."
Jun 26, 2025
5.0
"Dr Nguyen is amazing!"
Jun 26, 2025
4.0
"I very much appreciated Dr Nguyen calling me a couple of weeks later to follow up on my diagnosis.He also said that he would let me know If there are any upcoming trials for my cancer conditions"
Jun 25, 2025
5.0
"I am very happy with the team of doctors that are treating me. I feel very confident with the individual doctor's expertise in a group discussion to evaluate my treatment."
Jun 25, 2025
5.0
"Dr Nguyen was very informative and knowledgeable about my diagnosis. He explained to us what to expect and gave the details of the procedures that are to follow. He has a great bed side manner."
Jun 24, 2025
5.0
"The staff does everything it can do to make the experience pleasant. They are great."
Jun 24, 2025
5.0
"Very good"
Jun 24, 2025
5.0
"Very good experience"