Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors: A Multi-Center Randomized Double-Blinded Controlled Trial

Inclusion Criteria:

• The participant must provide study-specific informed consent prior to any study specific procedures and authorization permitting release of personal health information.
• The participant must have a first time diagnosis of non-metastatic breast cancer which is Stage I-III.
• The participant must have a score of less than 12 on the PROMIS Adult v2.0 - Cognitive Function 4a.
• Participants with greater than or equal to 6 months to 5 years post-treatment (completion of initial surgery +/- adjuvant chemotherapy/radiation therapy) except may still be taking endocrine therapy or HER2-directed adjuvant therapy.
• The participant must be able to understand, speak, read, and write in English or Spanish

Exclusion Criteria:

• Scoring less than or equal to 3 on the 6-item cognitive screen
• Patient Health Questionnaire-2 item (PHQ-2) score of greater than or equal to 3
• Definitive clinical or radiologic evidence of metastatic disease
• Prior history of past or current other cancer, except for non-melanoma skin cancer or in situ cervical cancer within the past 5 years
• Previous exposure to chemotherapy treatment for another cancer or due to other medical condition (e.g. methotrexate exposure for treatment of rheumatoid arthritis)
• Previous central nervous system (CNS) radiation, intrathecal therapy or CNS-involved surgery
• Participants with history of stroke, traumatic brain injury, brain surgery, Alzheimer's disease or other dementia
• Participants with active substance abuse and/or in treatment for substance abuse, or history of bipolar disorder, psychosis, schizophrenia, ADHD, or learning disability.