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Clinical trials

Cancer Treatment Centers of America (CTCA) is committed to bringing you new and innovative investigational cancer treatment options. One way we do this is by participating in cancer research trials and studies.

For more information regarding clinical trials, please email the Clinical Trials team at clinicaltrials@ctca-hope.com or contact one of our Oncology Information Specialists at 888-841-9129. Oncology Information Specialists are available around the clock, 24 hours a day, 7 days a week, to discuss treatment options offered at CTCA.

Breast cancer

L-glutamine Supplementation to Alleviate Symptoms of Taxane-Induced Neuropathy in Patients with Breast Cancer

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This trial is offered at the following facilities: Eastern Regional Medical Center

A Phase 3, Open-Label, Randomized, Parallel, 2-Arm, Multi-Center Study of BMN 673 versus Physician’s Choice in Germline BRCA Mutation Subjects with Locally Advanced and/or Metastatic Breast Cancer, Who Have Received No More than 2 Prior Chemotherapy Regimens for Metastatic Disease

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This trial is offered at the following facilities: Eastern Regional Medical Center

A Randomized Multicenter Pivotal Study of CDX-011 (CR011-vcMMAE) in Patients with Metastatic, GPNMB Over-Expressing, Triple-Negative Breast Cancer.

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This trial is offered at the following facilities: Midwestern Regional Medical Center

A Randomized, Phase 2 Study of the Efficacy and Tolerability of Veliparib in Combination with Temozolomide or Veliparib in Combination with Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Subjects with BRCA1 or BRCA2 Mutation and Metastatic Breast Cancer

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This trial is offered at the following facilities: Midwestern Regional Medical Center

PUMA-NER-1301: A Study of Neratinib plus Capecitabine vs. lapatinib plus Capecitabine in patients with HER2+ metastatic breast cancer who have received two or more prior HER2 directed regimens in the metastatic setting

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This trial is offered at the following facilities: Midwestern Regional Medical Center

Temsirolimus Plus Neratinib for Patients With Metastatic HER2-Amplified or Triple Negative Breast Cancer

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This trial is offered at the following facilities: Western Regional Medical Center

Meso BioMatrix Acellular Peritoneum Matrix Breast Reconstruction Feasibility Trial

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This trial is offered at the following facilities: Eastern Regional Medical Center

A Phase 3 Randomized, Placebo-Controlled Trial of Carboplatin and Paclitaxel With or Without the PARP Inhibitor Veliparib (ABT-888) in HER2-NegativeMetastatic or Locally Advanced Unresectable BRCA-Associated Breast Cancer

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This trial is offered at the following facilities: Midwestern Regional Medical Center

A Phase I/II Study Evaluating the Maximum Tolerated Dose, Bioequivalence/Pharmacokinetics, Safety and Efficacy of Hyperthermia and Thermodox® (Lyso-Thermosensitive Liposomal Doxirubicin) in Patients with Local-Regional Recurrent Breast Cancer

This trial is offered at the following facilities: Southwestern Regional Medical Center

Identification And Analysis Of Families With Genetic Susceptibility To Cancer

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This trial is offered at the following facilities: Eastern Regional Medical Center

Metronomic Capecitabine with Digoxin for Metastatic Breast Cancer Progressing After Anthracycline and Taxane Treatment

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This trial is offered at the following facilities: Western Regional Medical Center

A Phase Ib/II Study of Pembrolizumab and Monoclonal Antibody Chemotherapy in Patients with Advanced Cancer (PembroMab)

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This trial is offered at the following facilities: Western Regional Medical Center

Colorectal cancer

A Phase Ib/II Study of Pembrolizumab and Monoclonal Antibody Chemotherapy in Patients with Advanced Cancer (PembroMab)

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This trial is offered at the following facilities: Western Regional Medical Center

Endometrial cancer

An Open-Label, Randomized, Multi-Center, Prospective Study of the Instillation Technique Using The Modified Intra- Uterine Manipulator Catheter With Methylene Blue, Isosulfan Blue or Indocyanine Green Dyes, Compared to Cervical Injection, For Sentinel Lymph Node Detection in Endometrial Carcinoma

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This trial is offered at the following facilities: Southeastern Regional Medical Center

General

Modular phase II study to link targeted therapy to patients with pathway activated tumors: Module - 1 BKM120 for patients with PI3K-activated tumors

The purpose of this signal seeking study is to determine whether treatment with BKM120 demonstrates sufficient efficacy in select pathway-activated solid tumors (and/or hematologic malignancies) to warrant further study.

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This trial is offered at the following facilities: Southeastern Regional Medical Center

Modular phase II study to link targeted therapy to patients with pathway activated tumors: Module 8 – LEE011 for patients with CDK4/6 pathway activated tumors

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This trial is offered at the following facilities: Southeastern Regional Medical Center

Total Marrow and Lymphatic Irradiation (TMLI) in the preparatory regimens for hematologic malignancies

This trial is offered at the following facilities: Southwestern Regional Medical Center

Compassionate Use of Omegaven in the Treatment of Parenteral Nutrition Induced Hepatic Injury

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This trial is offered at the following facilities: Midwestern Regional Medical Center

A Phase I, open-label, multiple-ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of MSB0010718C in subjects with metastatic or locally advanced solid tumors and expansion to selected indications

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This trial is offered at the following facilities: Western Regional Medical Center

My Pathway: An Open-Label Phase IIA Study Evaluating Trastuzumab/Pertuzumab, Erlotinib, Vemurafenib, and Vismodegib in Patients Who Have Advanced Solid Tumors with Mutations or Gene Expression Abnormalities Predictive of Response to One of These Agents

View the trial        Western Regional Medical Center: Request more information

                                Eastern Regional Medical Center: Request more information

                                Midwestern Regional Medical Center: Request more information

This trial is offered at the following facilities: Western Regional Medical Center, Eastern Regional Medical Center, Midwestern Regional Medical Center

A rollover study to provide continued treatment with GSK1120212 to subjects with solid tumors or leukemia

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This trial is offered at the following facilities: Western Regional Medical Center

A rollover study to provide continued treatment with GSK2118436 to subjects with BRAF mutation-positive tumors

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This trial is offered at the following facilities: Western Regional Medical Center

Modular Phase II Study to Link Targeted Therapy to Patients With Pathway Activated Tumors: Module 4 - LGX818 for Patients With BRAFV600 Mutated Tumors

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This trial is offered at the following facilities: Southeastern Regional Medical Center

Modular phase II study to link targeted therapy to patients with pathway activated tumors: Module 2 - Dovitinib for patients with tumor pathway activations inhibited by dovitinib including tumors with mutations or translocations of FGFR, PDGFR, VEGF, cKIT, FLT3, CSFR1, Trk and RET

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This trial is offered at the following facilities: Eastern Regional Medical Center, Midwestern Regional Medical Center, Southeastern Regional Medical Center, Southwestern Regional Medical Center

Modular phase II study to link targeted therapy to patients with pathway activated tumors: Module 3 - MEK162 for patients with RAS/RAF/MEK activated tumors

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This trial is offered at the following facilities: Southeastern Regional Medical Center

Modular Phase II Study to Link Targeted Therapy to Patients With Pathway Activated Tumors: Module - 5 LDE225 for Patients With PTCH1 or SMO Mutated Tumors

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This trial is offered at the following facilities: Southeastern Regional Medical Center

Combination Tissue Plasminogen Activator (TPA) and Dornase Alpha (DNASE) Administration through Intrapleural Catheters for the Treatment of Loculated or Non-Draning Malignant Pleural Effusions

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This trial is offered at the following facilities: Eastern Regional Medical Center

Modular Phase II Study to Link Targeted Therapy to Patients With Pathway Activated Tumors: Module - 7 Ceritinib (LDK378) for Patients Whose Tumors Have Aberrations in ALK or ROS1

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This trial is offered at the following facilities: Southeastern Regional Medical Center

Head and neck cancer

Use of Low Level Laser Therapy (LLLT) for the Treatment of Radiation Therapy Induced Oral Mucositis

This trial is offered at the following facilities: Southwestern Regional Medical Center

A Phase Ib/II Study of Pembrolizumab and Monoclonal Antibody Chemotherapy in Patients with Advanced Cancer (PembroMab)

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This trial is offered at the following facilities: Western Regional Medical Center

Hodgkin lymphoma

Randomized, Open-label, Phase 3 Trial of A+AVD Versus ABVD as Frontline Therapy in Patients With Advanced Classical Hodgkin Lymphoma

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This trial is offered at the following facilities: Midwestern Regional Medical Center

Lung cancer

A randomized, multi-center phase 2 trial of denosumab in combination with chemotherapy as first- line treatment of metastatic non-small cell lung cancer

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This trial is offered at the following facilities: Western Regional Medical Center

A Phase IIa, Open-Label, Multi-Center, Multi-Cohort, Immune-Modulated Study of Selected Small Molecules (Gefitinib, AZD9291, or Selumetinib + Docetaxel) or a 1st Immune-Mediated Therapy (IMT; Tremelimumab) with a Sequential Switch to a 2nd IMT (MEDI4736) in Patients with Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (Stage IIIB-IV)

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This trial is offered at the following facilities: Western Regional Medical Center

A safety trial of nivolumab (BMS-936558) in subjects with advanced or metastatic non-small cell lung cancer who have progressed during or after receiving at least one prior systemic regimen

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This trial is offered at the following facilities: Western Regional Medical Center, Southeastern Regional Medical Center

Metastatic lung cancer trial

Efficacy Study of AuroLase Therapy in Subjects With Primary and/or Metastatic Lung Tumors.

This study is for patients who have either primary or metastatic tumors of the lung where there is airway obstruction. This single treatment session involves the infusion of ‘nanoparticles’ (AuroShell particles) that collect in tumors which are then treated with a laser that heats the tumor cells and spares healthy tissue. This study will assess the safety of this therapy, as well as the efficacy of AuroLase therapy in destroying the targeted lesion.

This trial is offered at the following facilities: Eastern Regional Medical Center

An Open-Label, Multicenter, Single-Arm, Expanded Access Study of Alectinib For Patients with Anaplastic Lymphoma Kinase-Rearranged Non-Small Cell Lung Cancer Previously Treated with Crizontinib

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This trial is offered at the following facilities: Eastern Regional Medical Center

Randomized, Double-blind, Multicenter, Phase 3 Study Comparing Veliparib plus Carboplatin and Paclitaxel versus Placebo plus Carboplatin and Paclitaxel in Previously Untreated Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

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This trial is offered at the following facilities: Midwestern Regional Medical Center

Study of carfilzomib with irinotecan in irinotecan-sensitive malignancies and small cell lung cancer patients

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This trial is offered at the following facilities: Western Regional Medical Center

Lymphoma

A Phase 3b Randomized Study of Lenalidomide (CC-5013) Plus Rituximab Maintenance Therapy Followed by Lenalidomide Single-Agent Maintenance Versus Rituximab Maintenance in Subjects with Relapsed/Refractory Follicular, Marginal Zone or Mantle Cell Lymphoma

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This trial is offered at the following facilities: Southeastern Regional Medical Center

Melanoma

Dacarbazine and Carmustine in Metastatic Melanoma

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This trial is offered at the following facilities: Southwestern Regional Medical Center

A safety study for MSB0010445 in combination with stereotactic body radiation in advanced melanoma subjects following prior treatment with ipilimumab

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This trial is offered at the following facilities: Western Regional Medical Center

Non-Hodgkin lymphoma (NHL)

Oncoquest-L Vaccine in Patients With Previously Untreated Stage III or IV, Asymptomatic, Non-bulky Follicular Lymphoma

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This trial is offered at the following facilities: Midwestern Regional Medical Center

Non-small cell lung cancer (NSCLC)

An Open Label, Multicenter, Phase 2 Study to Determine the Safety and Efficacy of BIND-014 (Docetaxel nanoparticles for injectable suspension) as Second-line Therapy for Patients with K-ras Mutation Positive Non-small Cell Lung Cancer

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This trial is offered at the following facilities: Western Regional Medical Center

A Phase IIa, Open-Label, Multi-Center, Multi-Cohort, Immune-Modulated Study of Selected Small Molecules (Gefitinib, AZD9291, or Selumetinib + Docetaxel) or a 1st Immune-Mediated Therapy (IMT; Tremelimumab) with a Sequential Switch to a 2nd IMT (MEDI4736) in Patients with Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (Stage IIIB-IV)

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This trial is offered at the following facilities: Western Regional Medical Center

A Global Study to Assess the Effects of MEDI4736 in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer (ATLANTIC)

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This trial is offered at the following facilities: Western Regional Medical Center

A randomized, multi-center phase 2 trial of denosumab in combination with chemotherapy as first- line treatment of metastatic non-small cell lung cancer

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This trial is offered at the following facilities: Western Regional Medical Center

A Phase III, Randomized, Double-blind, Placebo-controlled, Multi-centre, International Study of MEDI4736 as Sequential Therapy in Patients with Locally Advanced, Unresectable Non-Small Cell Lung Cancer (Stage III) Who Have Not Progressed Following Definitive, Platinum-based, Concurrent Chemoradiation Therapy (PACIFIC)

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This trial is offered at the following facilities: Western Regional Medical Center

A safety trial of nivolumab (BMS-936558) in subjects with advanced or metastatic non-small cell lung cancer who have progressed during or after receiving at least one prior systemic regimen

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This trial is offered at the following facilities: Western Regional Medical Center

Ovarian cancer

A Phase Ib/II Study of Pembrolizumab Plus Chemotherapy in Patients with Advanced Cancer (PembroPlus)

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This trial is offered at the following facilities: Western Regional Medical Center

Platinum-Gemcitabine-Avastin (PGA) for Platinum-resistant/refractory, Paclitaxel-Pretreated Recurrent Ovarian and Peritoneal Carcinoma

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This trial is offered at the following facilities: Western Regional Medical Center

Pancreatic cancer

Multi-Modality Therapy for Untreated Patients with Resectable or Marginally Resectable Pancreatic Cancer.

This trial is offered at the following facilities: Southwestern Regional Medical Center

A Phase Ib/II Study of Pembrolizumab Plus Chemotherapy in Patients with Advanced Cancer (PembroPlus)

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This trial is offered at the following facilities: Western Regional Medical Center

A phase II study evaluating bi-weekly dosing of gemcitabine plus nab-Paclitaxel in the treatment of treatment of surgically unresectable/metastatic pancreatic cancer.

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This trial is offered at the following facilities: Western Regional Medical Center

A phase 1b/2 study of OMP-59R5 in combination with nab-paclitaxel and gemcitabine in subjects with previously untreated Stage IV pancreatic cancer

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This trial is offered at the following facilities: Western Regional Medical Center

Pelvic cancer

Evaluation of Hyperthermia and Radiotherapy for the Treatment of Patients with Locally Advanced Tumors of the Pelvis.

This trial is offered at the following facilities: Southwestern Regional Medical Center, Eastern Regional Medical Center

Sarcoma, soft tissue

A Randomized Controlled Study of YONDELIS(R)(Trabectedin) or Dacarbazine for the treatment of Advanced Liposarcoma or Leiomyosarcoma Previously Treated With an Anthracycline and Ifosfamide.

This trial is offered at the following facilities: Southwestern Regional Medical Center

A Multicenter, Open-Label Single Arm Study of Yondelis(R)(Trabectedin)for Subjects with Locally Advanced or Metastatic Soft Tissue Sarcoma Excluding Leiomyosarcoma and Liposarcoma Who Have Relapse or Are Refractory to Standard of Care

This trial is offered at the following facilities: Southwestern Regional Medical Center

Soft tissue sarcoma

A Phase Ib/II Study of Pembrolizumab Plus Chemotherapy in Patients with Advanced Cancer (PembroPlus)

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This trial is offered at the following facilities: Western Regional Medical Center

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