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Cancer Treatment Centers of America

Vinorelbine (Navelbine®)


Brand Name: Navelbine®

Vinorelbine is used in the treatment of lung cancer, and may also be used in the treatment of other types of cancer.

Vinorelbine is a chemotherapy drug. Specifically, this medicine belongs to a class of drugs called plant alkaloids. Normal cells divide (reproduce) in a regulated way. Tumors are made of cells that divide in an uncontrolled way. Cell division follows a step-by-step cycle that relies on certain structures within the cell. Vinorelbine attacks cells during certain phases of cell division and prevents the formation of some structures that cells need in order to reproduce.

This medication is given as an injection or infusion into a vein. The exact dose and schedule varies depending on the type of cancer being treated, the extent of disease, and other factors. Vinorelbine can cause severe tissue damage and blistering if it escapes from the vein. If you notice pain, redness or swelling where the drug was injected, inform your doctor or nurse immediately.

Vinorelbine side effects

To prevent problematic interactions between vinorelbine and other drugs, be sure to tell your doctor if you are allergic to any medications, and what other medications and supplements you are currently taking. You should also inform your doctor if you have or ever had diabetes, high blood pressure, stomach ulcers, liver tumor, liver disease, or kidney disease, if you are pregnant or planning to become pregnant, or if you are breastfeeding. Women should not breastfeed while taking vinorelbine.

Possible side effects from taking vinorelbine may include:

  • Nausea or vomiting
  • Muscle weakness
  • Constipation
  • Pain where the drug was injected or infused
  • Diarrhea
  • Hair loss

Some of vinorelbine’s side effects can be serious. Call your doctor immediately if you experience any of these symptoms:

  • Fever, sore throat, chills, or other signs of infection
  • Nausea that is not relieved by prescribed medication
  • Vomiting or diarrhea more than 4-5 times within 24 hours
  • Unusual bleeding or bruising
  • Black or tarry stools
  • Blood in stools or urine
  • Lip or mouth sores
  • Constipation

Please note that this is not a comprehensive list. Patients may experience additional effects not mentioned above.

At Cancer Treatment Centers of America (CTCA), your team of cancer experts will explain each of the side effects of vinorelbine with you in detail, as well as the side effects and expectations of all other medications planned as part of your individualized treatment plan.

Vinorelbine for cancer treatment

Vinorelbine is approved by the FDA for the treatment of:

  • Previously untreated unresectable, advanced non-small cell lung cancer (NSCLC), as a single agent or in combination with cisplatin
  • Stage IV NSCLC, as a single agent or in combination with cisplatin
  • Stage III NSCLC, in combination with cisplatin

At Cancer Treatment Centers of America (CTCA), our integrative approach to cancer treatment works to fight your disease on all fronts and ensures that you remain at the center of everything we do. We encourage participation from both you and your family to make certain you are comfortable with all decisions made regarding your treatment.

The information provided here is for educational purposes only. In no way should it be considered as offering medical advice. Cancer Treatment Centers of America assumes no responsibility for how this material is used. Please check with a physician if you suspect you are ill. Also note that while Cancer Treatment Centers of America frequently updates its contents, medical information changes rapidly. Therefore, some information may be out of date.