Targeted therapy for melanoma
Targeted therapy drugs are designed to identify receptors, genes or other specific proteins unique to certain cancer cells. Once these drugs have reached their target, they may act alone to kill cancer cells or help other therapies, such as chemotherapy, work better. Among the drugs used in targeted therapy are so-called kinase inhibitors, which target specific enzymes or mutated genes that help regulate cell growth.
Vemurafenib (Zelboraf®), dabrafenib (Tafinlar®) and trametinib (Mekinist®) are common targeted therapy drugs approved to treat advanced metastatic melanoma that cannot be treated with surgery. Dabrafenib (Tafinlar®) and trametinib (Mekinist®) have been approved to be used in combination to treat unresectable or metastatic melanoma. These drugs target a mutated form of a protein called BRAF, which is involved in the growth of melanoma cells.
What is targeted therapy?
Targeted therapies are drugs or other substances designed to block the growth and spread of cancer by preventing cancer cells from dividing or by destroying them directly. While standard chemotherapy affects all cells in the body, targeted therapy directs drugs or other specially created substances (e.g., immune system proteins developed in the lab) to attack cancer cells. The goal of targeted therapy is to interfere with genes or proteins involved in tumor growth to block the spread of the disease.
By targeting specific molecules that are responsible for the growth, progression and spread of cancer, targeted therapy differs from standard chemotherapy, which attacks the disease systemically and, therefore, also damages healthy cells. Because targeted therapy specifically seeks out cancer cells, it is designed to reduce the harm to healthy cells, which may lead to fewer side effects than standard chemotherapy.
Targeted therapies serve as the foundation of precision medicine, which uses information about a person’s genes or a tumor’s DNA profile to identify additional treatment options. Tailored treatments target abnormalities that may be found in each tumor’s DNA profile. This innovation marks a shift from traditional treatments designed for the average patient, toward more precise therapies.
Targeted therapy is an evolving science, and not all cancer types may be treated with targeted drugs. Several targeted therapies have been approved by the U.S. Food and Drug Administration for use in cancer treatment, including hormone therapies, immunotherapies, signal transduction inhibitors, apoptosis inducers, gene expression modulators, angiogenesis inhibitors and toxin delivery molecules.
To help identify an appropriate targeted therapy for your cancer, your doctor may order tests to learn more about the genetic disposition, protein composition and other factors the tumor exhibits. Patients may be a candidate for targeted therapy if the cancer did not respond to other therapies, has spread, is inoperable or meets other criteria. Targeted therapy may also be combined with surgery, chemotherapy, radiation therapy or hormone therapy.
Targeted therapy may be prescribed as oral pills, administered intravenously or delivered in other ways. Targeted therapy drugs may be administered in the hospital, or prescribed in pill form and taken at home. The treatment schedule is specific to each person and his or her cancer.